Serum leptin concentrations are not related to dietary patterns but are related to sex, age, body mass index, serum triacylglycerol, serum insulin, and plasma glucose in the US population
Serum leptin concentrations are not related to dietary patterns but are related to sex, age, body mass index, serum triacylglycerol, serum insulin, and plasma glucose in the US population
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DOI：
10.1186/1743-7075-6-3
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发表时间：
2009-01-14
影响因子：
4.5
通讯作者：
McCarthy, Erin
中科院分区：
文献类型：
--
作者：
Ganji, Vijay;Kafai, Mohammad R.;McCarthy, Erin
背景：已知瘦素在食物摄入调节中起作用。本研究的目的是调查美国人群血清瘦素浓度与饮食模式、人口统计学、生活方式和健康因素之间的关系。1988-1994年第三次全国健康与营养调查的数据被用来研究空腹血清瘦素与饮食模式、性别、种族、吸烟、年龄、能量和酒精摄入之间的关系，体重指数（BMI），血糖，血清三酰甘油和血清胰岛素在4009人。结果：蔬菜、水果和瘦肉型膳食模式（8.5fg/L）和混合型膳食模式（8.0fg/L）的血清瘦素浓度显著高于西方膳食模式（6.29fg/L）（P < 0.0001）;当分析调整混杂变量，血清瘦素和饮食模式之间没有显着的关联（P = 0.22）。多元校正的血清瘦素浓度与性别显著相关（女性高于男性; beta = -1.052; P < 0.0001），年龄（直接相关，β = 0.006，P < 0.0001），BMI，（直接相关，β = 0.082，P < 0.0001），空腹血糖（负相关，β =-0.024，P = 0.0146），血清三酰甘油（直接相关，β = 0.034，P = 0.0022），血清胰岛素（直接相关，β = 0.003，P < 0.0001），但与人种-种族无关（P = 0.65）、吸烟（P = 0.20）、能量摄入（P = 0.42）和饮酒（P = 0.73）。性别、年龄、BMI、血清甘油三酯、血糖和血清胰岛素是血清瘦素浓度的独立预测因子。
Background: Leptin is known to play a role in food intake regulation. The aim of this study was to investigate the relation between serum leptin concentrations and dietary patterns and demographic, lifestyle, and health factors in the US population.Methods: Data from the third National Health and Nutrition Examination Survey, 1988-1994 were used to study the association between fasting serum leptin and dietary patterns, sex, race-ethnicity, smoking, age, energy and alcohol intakes, body mass index (BMI), plasma glucose, serum triacylglycerol, and serum insulin in 4009 individuals. Factor analysis was used to derive three principle factors and these were labeled as Vegetable, Fruit, and Lean Meat, Western, and Mixed dietary patterns.Results: Serum leptin concentrations were significantly higher in Vegetable, Fruit, and Lean Meat (8.5 fg/L) and Mixed patterns (8.0 fg/L) compared to Western pattern (6.29 fg/L) (P < 0.0001). When analysis was adjusted for confounding variables, no significant association was observed between serum leptin and dietary patterns (P = 0.22). Multivariate adjusted serum leptin concentrations were significantly associated with sex (higher in women than in men; beta = -1.052; P < 0.0001), age (direct relation, beta = 0.006, P < 0.0001), BMI, (direct relation, beta = 0.082, P < 0.0001), fasting plasma glucose (inverse relation, beta = -0.024, P = 0.0146), serum triacylglycerol (direct relation, beta = 0.034, P = 0.0022), and serum insulin (direct relation, beta = 0.003, P < 0.0001) but not with race-ethnicity (P = 0.65), smoking (P = 0.20), energy intake (P = 0.42), and alcohol intake (P = 0.73).Conclusion: In this study, serum leptin was not independently associated with dietary patterns. Sex, age, BMI, serum triacylglycerol, plasma glucose, and serum insulin are independent predictors of serum leptin concentrations.