Mouse models for human familial adenomatous polyposis
Mouse models for human familial adenomatous polyposis
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DOI：
10.1006/scbi.2001.0368
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发表时间：
2001-06-01
影响因子：
14.5
通讯作者：
Edelmann, W
中科院分区：
文献类型：
--
作者：
Kucherlapati, R;Lin, DP;Edelmann, W
Colorectal cancer (CRC) is the second most frequent type of cancer in the Western hemisphere. In the United States alone, it is estimated that 150000 new eases are detected every year and more than (65 000 patients die from complications associated with this cancer Identification of genes implicated in the initiation and progression of colorectal cancer in humans has prompted the generation of mouse models for this cancer. We will provide a brief overview of these mouse models for CRC and what they have contributed to our understanding of the events involved in the initiation and progression of this cancer.
