Coronavirus Proteins as Ion Channels: Current and Potential Research.
Coronavirus Proteins as Ion Channels: Current and Potential Research.
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DOI：
10.3389/fimmu.2020.573339
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发表时间：
2020
影响因子：
7.3
通讯作者：
Nichols CG
中科院分区：
文献类型：
--
作者：
McClenaghan C;Hanson A;Lee SJ;Nichols CG
冠状病毒（CoV）爆发最近已成为全球公共卫生威胁，这是由于其特殊的人畜共患病潜力-这一特征源于其感染各种潜在宿主的能力以及其高突变和重组能力。在2003年的严重急性呼吸综合征（SARS）CoV-1和2012年的中东呼吸综合征（MERS）CoV之后，随着目前的SARS-CoV-2大流行，我们现在正处于不到20年来第三次致命的国际CoV爆发之中。冠状病毒爆发对全球公共卫生构成严重威胁，迫切需要治疗方案。在这里，我们严格审查目前的证据，离子通道活动的冠状病毒蛋白和调制作为一种治疗方法的潜力。
Coronavirus (CoV) outbreaks have recently emerged as a global public health threat due to their exceptional zoonotic potential — a feature arising from their ability to infect a diverse range of potential hosts combined with their high capacity for mutation and recombination. After Severe Acute Respiratory Syndrome (SARS) CoV-1 in 2003 and Middle East Respiratory Syndrome (MERS) CoV in 2012, with the current SARS-CoV-2 pandemic we are now in the midst of the third deadly international CoV outbreak in less than 20 years. Coronavirus outbreaks present a critical threat to global public health and an urgent necessity for therapeutic options. Here, we critically examine the current evidence for ion channel activity in CoV proteins and the potential for modulation as a therapeutic approach.