Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays.
Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays.
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DOI：
10.1038/s41551-021-00763-4
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发表时间：
2021-07-01
影响因子：
28.1
通讯作者：
Xu, Sheng
中科院分区：
文献类型：
--
作者：
Wang, Chonghe;Qi, Baiyan;Xu, Sheng
用于连续监测来自深层组织的生理信号的可伸展可穿戴设备受到信号穿透深度和分辨来自特定组织的信号的困难的限制。在这里，我们报告了一种皮肤共形超声相控阵的原型的开发和测试，用于监测皮肤下14厘米以下组织的血流动力学信号。该设备允许在一定范围的入射角度上主动聚焦和引导超声波光束，以便瞄准感兴趣的区域。在健康志愿者身上，我们展示了相控阵可以用于监测心脏组织的多普勒频谱，记录中心血流波形，并实时估计脑供血。可伸展和适形皮肤穿戴的超声波相控阵可能为可穿戴诊断打开机会。
Stretchable wearable devices for the continuous monitoring of physiological signals from deep tissues are constrained by the depth of signal penetration and by difficulties in resolving signals from specific tissues. Here, we report the development and testing of a prototype skin-conformal ultrasonic phased array for the monitoring of haemodynamic signals from tissues up to 14cm beneath the skin. The device allows for active focusing and steering of ultrasound beams over a range of incident angles so as to target regions of interest. In healthy volunteers, we show that the phased array can be used to monitor Doppler spectra from cardiac tissues, record central blood flow waveforms and estimate cerebral blood supply in real time. Stretchable and conformal skin-worn ultrasonic phased arrays may open up opportunities for wearable diagnostics.