THE TREATMENT OF MELASMA - 20-PERCENT AZELAIC ACID VERSUS 4-PERCENT HYDROQUINONE CREAM
THE TREATMENT OF MELASMA - 20-PERCENT AZELAIC ACID VERSUS 4-PERCENT HYDROQUINONE CREAM
复制标题
DOI：
10.1111/j.1365-4362.1991.tb04362.x
复制
发表时间：
1991-12-01
影响因子：
3.6
通讯作者：
GRAUPE, K
中科院分区：
文献类型：
--
作者：
BALINA, LM;GRAUPE, K
在一项为期24周的双盲研究中，对329名女性进行了20%壬二酸霜和4%氢醌霜与广谱防晒霜联合使用对黄褐斑的疗效研究。 在治疗期间，壬二酸乳膏产生了65%的良好或极佳结果;在总体评级、病变大小减小和色素沉着强度方面未观察到显著的治疗差异。 壬二酸未观察到严重的副作用，如过敏性致敏或外源性褐变。
The efficacy of 20% azelaic acid cream and 4% hydroquinone cream, both used in conjunction with a broad-spectrum sunscreen, against melasma was investigated in a 24-week, double-blind study with 329 women. Over the treatment period the azelaic acid cream yielded 65% good or excellent results; no significant treatment differences were observed with regard to overall rating, reduction in lesion size, and pigmentary intensity. Severe side effects such as allergic sensitization or exogenous ochronosis were not observed with azelaic acid.