Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women
Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women
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DOI：
10.1016/s0378-5122(03)00282-2
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发表时间：
2004-03-15
期刊：
影响因子：
4.9
通讯作者：
Stergiopoulos, K
中科院分区：
文献类型：
--
作者：
Papakitsou, EF;Margioris, AN;Stergiopoulos, K
目的：本研究的目的是评估体重指数(BMI)增加作为人体测量因素，在绝经后易导致骨转换率降低或骨平衡改变。材料与方法：对130例46~85岁健康绝经后妇女进行体重指数、脊柱骨密度、股骨骨密度及骨形成生化指标(血清骨钙素、血清前胶原C肽、血清骨特异性碱性磷酸酶、骨吸收)、尿I型胶原N端和C端交联端肽(U-NTX-I和U-CTX-I)、吡啶啉(U-PYD)和脱氧吡啶(U-DPD)的测定。骨平衡指数由形成标志物的z分值减去吸收标志物的z分值计算，以评价骨平衡。结果：S-PICP值(r=-0.297，P=0.002)、S-OC值(r=-0.173)、骨平衡指数(ZPICPZDPD)和骨平衡指数(ZPICPZPYD)呈负相关。与体重指数(r=-0.25P=0.037)和骨密度(r=-0.196，P=0.032和r=-0.275，P=0.022)呈正相关。女性根据她们的BMI分为正常组(BMI和体重指数25 kg/m(2))、超重(BMI=25-30 kg/m(2))和肥胖组(BMI和Gt；30 kg/m(2))。超重和肥胖女性的S-PICP值分别为68.11+/-24.85和66.41+/-24.93 ng/mlvs97.47+/-23.36 ng/mlvs97.47+/-23.36 ng/ml，较正常人低约30%(P=0.0001)。肥胖组ZPICPZDPD、ZPICPZCTX-I和ZPICPZPYD均显著低于正常对照组(P=0.0072，0.02和0.0028)。结论：绝经后女性BMI与I型胶原形成标志物水平呈负相关，肥胖患者血清PICR减少，I型胶原形成有利于降解，但由于这一发现并不伴随着骨密度的降低，因此体重增加可能对成熟的雌激素缺乏的骨和含有I型胶原的骨骼外组织产生不同的影响。(C)2003爱思唯尔爱尔兰有限公司。
Objectives: Aim of this study was to evaluate increased body mass index (BMI) as an anthropometric factor, predisposing to lower rates of bone turnover or changes in bone balance after menopause. Material and methods: For this purpose, we calculated BMI, and measured spinal (BMDSP) and femoral bone mineral density (BMDFN) and biochemical markers of bone formation (serum osteocalcin (S-OC), serum procollagen type I C propeptide (S-PICP), serum bone-specific alkaline phosphatase (S-B-ALP)) and resorption (urine N- and C-terminal cross-linking telopeptide of type I collagen (U-NTX-I and U-CTX-I), pyridinoline (U-PYD) and deoxypyridinoline (U-DPD)) in 130 healthy postmenopausal women, aged 46-85 years. Bone balance indices were calculated by subtracting z-scores of resorption markers from z-scores of formation markers, to evaluate bone balance. Results: S-PICP (r = -0.297, P = 0.002), S-OC (r = -0.173, P = 0.05) and bone balance indices (zPICP-zDPD) and (zPICP-zPYD) were negatively. correlated with BMI (r = -0.25, P = 0.01 and r = -0.21, P = 0.037) and with BMDSP (r = -0.196, P = 0.032 and r = -0.275 and P = 0.022). Women were grouped according to their BMI, in normals (BMI < 25 kg/m(2)), overweight (BMI = 25-30 kg/m(2)), and obese (BMI > 30 kg/m(2)). Overweight and obese women had approximately 30% lower levels of S-PICP compared to normals (68.11 +/- 24.85 and 66.41 +/- 24.93 ng/ml versus 97.47 +/- 23.36 ng/ml, respectively; P = 0.0001). zPICP-zDPD, zPICP-zCTX-I and zPICP-zPYD were significantly declined in obese women compared to normals (P = 0.0072, 0.02 and 0.0028). Conclusions: We conclude that in postmenopausal women, BMI is inversely associated with levels of collagen I formation marker, serum PICR In obesity formation of collagen I was reduced, in favor of degradation, but since this finding is not followed by simultaneous decrease in bone mineral density, it seems that increased body weight may have different effects on mature estrogen-deficient bone and extraskeletal tissues containing collagen I. (C) 2003 Elsevier Ireland Ltd. All rights reserved.