Prognostic factors in advanced gastrointestinal cancer patients with weight loss
Prognostic factors in advanced gastrointestinal cancer patients with weight loss
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DOI：
10.1207/s15327914nc3701_4
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发表时间：
2000-01-01
影响因子：
2.9
通讯作者：
McArdle, CS
中科院分区：
文献类型：
--
作者：
O'Gorman, P;McMillan, DC;McArdle, CS
关于决定晚期胃肠道癌伴体重减轻患者生存率的因素的报道很少。在这些患者中（n = 91，中位体重减轻16.6%），我们前瞻性地研究了转移扩散、人体测量、血液参数、Karnofsky体力状态、食欲和急性期反应作为生存预测因子的重要性。计算从评估日期至最近一次就诊（大于或等于30个月）或直至死亡的生存期。多因素分析显示，转移扩散（p < 0.05）、Karnofsky体力状态（p < 0.01）和C反应蛋白浓度（p < 0.001）具有独立的预后价值。在局部晚期疾病（n = 64），Karnofsky性能状态和C-反应蛋白浓度仍然显着。有急性期反应的患者（中位136天）的生存期显著低于无反应的患者（中位466天; p < 0.01）。体力状态和急性期反应与晚期胃肠道癌患者的生存期相关，与体重减轻无关。
There are few reports on factors that determine survival in advanced gastrointestinal cancer with weight loss. In these patients (n = 91, median weight loss 16.6%), we prospectively examined the importance of metastatic spread, anthropometry, blood parameters, Karnofsky performance status, appetite, and the acute-phase response as predictors of survival. Survival was calculated from date of assessment to the most recent clinic attendance (greater than or equal to 30 mo) or until death. On multivariate analysis, metastatic spread (p < 0.05), Karnofsky performance status (p < 0.01), and C-reactive protein concentration (p < 0.001) had independent prognostic value. In locally advanced disease (n = 64), Karnofsky performance status and C-reactive protein concentration remained significant. There was a significantly lower survival in patients with an acute-phase response (median 136 days) than in patients with no response (median 466 days; p < 0.01). Performance status and the acute-phase response are associated, independent of weight loss, with survival duration in advanced gastrointestinal cancer patients.