Cancer chemoprevention by dietary polyphenols: promising role for epigenetics.
Cancer chemoprevention by dietary polyphenols: promising role for epigenetics.
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DOI：
10.1016/j.bcp.2010.06.036
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发表时间：
2010-12-15
影响因子：
5.8
通讯作者：
Goel, Ajay
中科院分区：
文献类型：
--
作者：
Link, Alexander;Balaguer, Francesc;Goel, Ajay
表观遗传学是指DNA序列本身不编码但在基因表达控制中起重要作用的可遗传变化。在哺乳动物中，表观遗传机制包括DNA甲基化、组蛋白修饰和非编码rna的变化。虽然表观遗传变化在体细胞中是可遗传的，但这些修饰也可能是可逆的，这使得它们成为定制癌症预防和治疗策略的有吸引力和有前途的途径。在过去的十年中，越来越多的证据提供了前所未有的线索，表明饮食和环境因素直接影响人类的表观遗传机制。来自绿茶、姜黄、大豆、西兰花等的膳食多酚在癌细胞中具有多种细胞调节活性。最近，我们开始了解到一些膳食多酚可能通过调节人类表观遗传机制的各种组成部分来发挥其化学预防作用。在本文中，我们首先讨论了饮食和环境因素对表观遗传改变的贡献；随后，我们对各种膳食多酚的作用进行了全面的文献综述。特别地，我们总结了目前关于大量膳食制剂及其在各种体外和体内模型中对DNA甲基化、组蛋白修饰和非编码mirna表达调控的影响的知识。我们强调如何增加对饮食多酚对特定表观遗传改变的化学预防作用的理解，可能为减少人类癌症和其他疾病的健康负担提供独特的、尚未探索的新颖而高效的化学预防策略。
Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but play an important role in the control of gene expression. In mammals, epigenetic mechanisms include changes in DNA methylation, histone modifications and non-coding RNAs. Although epigenetic changes are heritable in somatic cells, these modifications are also potentially reversible, which makes them attractive and promising avenues for tailoring cancer preventive and therapeutic strategies. Burgeoning evidence in the last decade has provided unprecedented clues that diet and environmental factors directly influence epigenetic mechanisms in humans. Dietary polyphenols from green tea, turmeric, soybeans, broccoli and others have shown to possess multiple cell-regulatory activities within cancer cells. More recently, we have begun to understand that some of the dietary polyphenols may exert their chemopreventive effects in part by modulating various components of the epigenetic machinery in humans. In this article, we first discuss the contribution of diet and environmental factors on epigenetic alterations; subsequently, we provide a comprehensive review of literature on the role of various dietary polyphenols. In particular, we summarize the current knowledge on a large number of dietary agents and their effects on DNA methylation, histone modifications and regulation of expression of non-coding miRNAs in various in vitro and in vivo models. We emphasize how increased understanding of the chemopreventive effects of dietary polyphenols on specific epigenetic alterations may provide unique and yet unexplored novel and highly effective chemopreventive strategies for reducing the health burden of cancer and other diseases in humans.
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DOI：
10.1158/1940-6207.capr-08-0142
发表时间：
2009-06
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Bhatnagar N;Li X;Chen Y;Zhou X;Garrett SH;Guo B
通讯作者：
Guo B
影响因子：
3
作者：
Beher, Dirk;Wu, John;Wang, Minghan
通讯作者：
Wang, Minghan
影响因子：
37.8
作者：
ARTAUDWILD, SM;CONNOR, SL;CONNOR, WE
通讯作者：
CONNOR, WE
影响因子：
4.8
作者：
Balasubramanyam, K;Varier, RA;Kundu, TK
通讯作者：
Kundu, TK
在小鼠表观遗传敏感等位基因上DNA甲基化的动态重编程。
影响因子：
4.5
作者：
Blewitt ME;Vickaryous NK;Paldi A;Koseki H;Whitelaw E
通讯作者：
Whitelaw E