SPINAL CORD STIMULATION MODULATES FRONTAL DELTA AND GAMMA IN PATIENTS OF MINIMALLY CONSCIOUSNESS STATE
SPINAL CORD STIMULATION MODULATES FRONTAL DELTA AND GAMMA IN PATIENTS OF MINIMALLY CONSCIOUSNESS STATE
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脊髓刺激调节微意识状态患者的额叶三角洲和伽马
DOI：
10.1016/j.neuroscience.2017.01.036
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发表时间：
2017-03-27
期刊：
影响因子：
3.3
通讯作者：
He, Jianghong
中科院分区：
文献类型：
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作者：
Bai, Yang;Xia, Xiaoyu;He, Jianghong
脊髓刺激（SCS）已被认为是治疗意识障碍（DOC）的一种治疗方法。虽然研究报告了其对患者的益处，但其潜在的病理生理机制尚不清楚。本研究的目的是测量SCS对处于最低意识状态（MCS）的患者脑电图的影响，这将使我们能够探索该方法的可能工作基础。记录11例MCS患者的静息状态脑电图，分别使用不同频率（5 Hz、20 Hz、50 Hz、70 Hz和100 Hz）。计算相对功率、相干性、s估计量和双相干性来评估脑电变化。在计算中划分了5个频带（delta、theta、alpha、beta和gamma）和3个区域（额、中、后）。本研究的主要发现是：(1)在5 Hz、70 Hz或100 Hz的刺激后，发现δ和γ波段的相对功率和同步性显著改变；(2)双相干性表明，在70 Hz的刺激下，δ内部的耦合明显减弱，而在5 Hz和100 Hz的刺激下，δ和γ之间的耦合减弱。然而，20 Hz、50 Hz和假刺激的SCS在任何区域都没有引起任何频段的变化。本研究显示脑电图证据表明，SCS可以通过激活形成-丘脑-皮层网络来调节MCS患者的脑功能。(c) 2017年。Elsevier Ltd.出版。版权所有。
Spinal cord stimulation (SCS) has been suggested as a therapeutic technique for treating patients with disorder of consciousness (DOC). Although studies have reported its benefits for patients, the underlying pathophysiological mechanisms remain unclear. The aim of this study was to measure the effects of SCS on the EEG of patients in a minimally conscious state (MCS), which would allow us to explore the possible workings underpinning of the approach. Resting state EEG was recorded before and immediately after SCS, using various frequencies (5 Hz, 20 Hz, 50 Hz, 70 Hz and 100 Hz), for 11 patients in MCS. Relative power, coherence, S-estimator and bicoherence were calculated to assess the EEG changes. Five frequency bands (delta, theta, alpha, beta and gamma) and three regions (frontal, central and posterior) were divided in the calculation. The main findings of this study were that: (1) significantly altered relative power and synchronisation was found in delta and gamma bands after one SCS stimulation using 5 Hz, 70 Hz or 100 Hz; (2) bicoherence showed that coupling within delta was significantly decreased after stimulation using 70 Hz, while reduction of coupling between delta and gamma was found when using 5 Hz and 100 Hz. However, SCS of 20 Hz, 50 Hz and sham stimulation did not induce changes in any frequency band at any region. This study showed EEG evidence that SCS can modulate the brain function of MCS patients, speculatively by activating the formation-thalamus-cortex network. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.