AN ALTERNATE FORMULATION OF BLOOD-VESSEL MECHANICS AND THE MEANING OF THE IN-VIVO PROPERTY
AN ALTERNATE FORMULATION OF BLOOD-VESSEL MECHANICS AND THE MEANING OF THE IN-VIVO PROPERTY
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DOI：
10.1016/0021-9290(94)00119-o
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发表时间：
1995-06-01
影响因子：
2.4
通讯作者：
VITO, RP
中科院分区：
文献类型：
--
作者：
BROSSOLLET, LJ;VITO, RP
为了弥合理论上基于血管力学和更简单的临床相关顺应性模型之间的差距，提出了一种替代的补充能量制剂以及改进的实验方法。该公式将单轴顺应性模型推广到多轴拉伸和扭曲，并阐明了总体内力（在双轴血管试验中测量）在血管稳定性中的作用。当假定不可压缩时，壁厚的测量和存在卸载状态的假设是不必要的。基于对血管力学的新认识，对临床和力学文献中的零散结果进行了重新解释，犬隐静脉（直径4-5 mm）符合分析预期的行为。它们在体内的性质被证明是一种被动的性质，独立于平滑肌张力。冗余的颗粒跟踪，力和压力值的控制和罂粟碱的使用，分别导致应变测量精确到0.002以内，实验控制精确到全范围的0.5%，以及几天内的可重复实验。经过验证的系统和新配方显示出巨大的潜力，利用创新的实验设计和统计可靠的数据分析的好处。
In an effort to bridge the gap between theoretically based vascular mechanics and simpler, clinically relevant compliance models, an alternative complementary energy formulation as well as an improved experimental method are proposed. This formulation generalizes the uniaxial compliance models to multiaxial stretch and twist and clarifies the role of the total in vivo force (measured in biaxial vascular testing) in vessel stability. The measurement of wall thickness when incompressibility is assumed, and the assumption of the existence of an unloaded state are unnecessary. Scattered results from both clinical and mechanical literature are reinterpreted in view of this new understanding of vascular mechanics.Canine saphenous veins (4-5 mm in diameter) conform to the behavior expected from the analysis. Their in vivo property is shown to be a passive property, independent of smooth muscle tone. Redundant particle tracking, control of force and pressure values and the use of papaverine, result, respectively, in strain measurements accurate to within 0.002, experimental control accurate to 0.5% of full range, and repeatable experiments over a few days. The validated system and the new formulation show great potential for exploiting the benefits of innovative experimental design and statistically reliable data analysis.