Examining the Electrical Excitation, Calcium Signaling, and Mechanical Contraction Cycle in a Heart Cell
Examining the Electrical Excitation, Calcium Signaling, and Mechanical Contraction Cycle in a Heart Cell
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检查心脏细胞中的电兴奋、钙信号传导和机械收缩周期
DOI：
10.30707/spora3.1deetz
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Zana Coulibaly
中科院分区：
文献类型：
--
作者：
K. Deetz;N. Foster;D. Leftwich;C. Meyer;Shalin Patel;C. Barajas;M. Gobbert;Zana Coulibaly
通讯作者：Matthias K. Gobbert，Department of Mathematics and Statistics，University of马里兰州，巴尔的摩县（UMBC），1000 Hilltop Circle，巴尔的摩，MD 21250，USA gobbert@umbc.edu摘要心脏病作为美国的主要死因，已成为现代社会的主要关注点.心律失常可由心肌细胞中钙动力学的失调引起。然而，钙调节异常尚未完全理解，也不容易预测;这为后续研究提供了动力。兴奋收缩偶联（ECC）是心肌细胞从动作电位开始收缩的过程.钙诱导的钙释放（CICR）是电兴奋与机械收缩通过钙信号耦合的机制。对电兴奋、钙信号和机械收缩之间相互作用的研究有可能提高我们对心肌细胞正常功能的理解，并帮助我们了解任何失调如何导致潜在的心律失常。ECC，其中CICR是一个重要的组成部分，可以使用偏微分方程的系统，链接的电兴奋，钙信号，和机械收缩心肌细胞的组成部分建模。我们扩展了先前的模型[Angeloff，Barajas等人，检查在心肌细胞中引入从电激励到钙动力学的链接的效果，Spora：生物数学杂志，2016年2月]以实现七变量模型，该模型首次包括ECC的机械组件。我们研究电和钙系统的相互作用如何影响心肌细胞的收缩水平。
Correspondence: Prof. Matthias K. Gobbert, Department of Mathematics and Statistics, University of Maryland, Baltimore County (UMBC), 1000 Hilltop Circle, Baltimore, MD 21250, USA gobbert@umbc.edu Abstract As the leading cause of death in the United States, heart disease has become a principal concern in modern society. Cardiac arrhythmias can be caused by a dysregulation of calcium dynamics in cardiomyocytes. Calcium dysregulation, however, is not yet fully understood and is not easily predicted; this provides motivation for the subsequent research. Excitationcontraction coupling (ECC) is the process through which cardiomyocytes undergo contraction from an action potential. Calcium induced calcium release (CICR) is the mechanism through which electrical excitation is coupled with mechanical contraction through calcium signaling. The study of the interplay between electrical excitation, calcium signaling, and mechanical contraction has the potential to improve our understanding of the regular functioning of the cardiomyocytes and help us understand how any dysregulation can lead to potential cardiac arrhythmias. ECC, of which CICR is an important part, can be modeled using a system of partial differential equations that link the electrical excitation, calcium signaling, and mechanical contraction components of a cardiomyocyte. We extend a previous model [Angeloff, Barajas, et al., Examining the effect of introducing a link from electrical excitation to calcium dynamics in a cardiomyocyte, Spora: A Journal of Biomathematics, 2, 2016] to implement a seven variable model that includes for the first time the mechanical component of the ECC. We study how the interaction of electrical and calcium systems can impact the cardiomyocyte’s levels of contraction.
影响因子：
3.4
作者：
Izu, LT;Mauban, JRH;Wier, WG
通讯作者：
Wier, WG
影响因子：
3.4
作者：
Izu, LT;Wier, WG;Balke, CW
通讯作者：
Balke, CW