Atrophy of hippocampal subfield CA2/3 in healthy elderly men is related to educational attainment
Atrophy of hippocampal subfield CA2/3 in healthy elderly men is related to educational attainment
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健康老年男性海马CA2/3亚区萎缩与受教育程度相关
DOI：
10.1016/j.neurobiolaging.2019.03.019
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发表时间：
2019-08-01
影响因子：
4.2
通讯作者：
Li, Chunbo
中科院分区：
文献类型：
--
作者：
Jiang, Lijuan;Cao, Xinyi;Li, Chunbo
高等教育水平是老年人认知能力下降的保护因素；然而，潜在的神经机制尚不清楚。海马体受年龄和教育的双重调节，是了解教育对人类大脑衰老的长期影响的起点。由于海马体具有功能异质的子区，并表现出性别差异，我们分别检查了男性和女性的海马体子区。我们对65-75岁的健康参与者进行了横断面（n = 143）和纵向（n = 51）分析，他们接受了结构磁共振成像。通过自动分割估计海马及其子区体积。我们发现受教育程度与男性海马CA2/3体积之间存在显著的正相关，但在女性中没有。针对该区域的纵向分析证实了上述结果，表明在15个月的随访期间，男性CA2/3区域较高的教育水平减轻了萎缩的进展。这些发现表明，在男性中，教育在特定海马体子区的衰老中起作用。(C) 2019 Elsevier Inc.版权所有。
A higher education level is a protective factor against cognitive decline in elders; however, the underlying neural mechanisms remain unclear. Modulated by both aging and education, the hippocampus is a starting point for understanding the long-lasting effect of education on the aging of human brain. Because the hippocampus possesses functionally heterogeneous subfields and exhibits sex differences, we examined hippocampal subfields in men and women separately. We performed both cross-sectional (n = 143) and longitudinal (n = 51) analyses on healthy participants aged 65-75 years, who underwent structural magnetic resonance imaging. Volumes of the hippocampi and their subfields were estimated by automated segmentation. We found significantly positive correlations between educational attainment and the volume of hippocampal CA2/3 in men but not in women. The longitudinal analysis focusing on this region validated the above results by showing that a higher education level attenuated the progression of atrophy during a 15-month follow-up period in the CA2/3 region in men. These findings suggest that, in men, education plays a role in the aging of specific hippocampal subfields. (C) 2019 Elsevier Inc. All rights reserved.