DAILY REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) IMPROVES MOOD IN DEPRESSION
DAILY REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) IMPROVES MOOD IN DEPRESSION
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DOI：
10.1097/00001756-199510020-00008
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发表时间：
1995-10-02
期刊：
影响因子：
1.7
通讯作者：
POST, RM
中科院分区：
文献类型：
--
作者：
GEORGE, MS;WASSERMANN, EM;POST, RM
越来越多的证据表明抑郁症患者的左前额皮质功能减退。重复经颅磁刺激（rTMS）激活大脑表面附近的神经元。我们质疑每日左前额叶rTMS是否可以改善抑郁症受试者的情绪，并报告了一项在6名高度抗药性抑郁症住院患者中进行的此类治疗的初步研究。整个组的抑郁评分显著改善（汉密尔顿抑郁评分从23.8 +/- 4.2（s.d.）基线至治疗后17.5 +/- 8.4; t = 3.03，5DF，p = 0.02，双尾配对t检验）。两名受试者表现出强烈的情绪改善，这在几周的过程中逐步发生。在一名受试者中，抑郁症状在3年内首次完全缓解。每日左前额叶rTMS似乎是安全的，耐受性良好，并可能减轻抑郁症。
CONVERGING evidence points to hypofunction of the left prefrontal cortex in depression. Repetitive transcranial magnetic stimulation (rTMS) activates neurons near the surface of the brain. We questioned whether daily left prefrontal rTMS might improve mood in depressed subjects and report a pilot study of such treatment in six highly medication-resistant depressed inpatients. Depression scores significantly improved for the group as a whole (Hamilton Depression Scores decreased from 23.8 +/- 4.2 (s.d.) at baseline to 17.5 +/- 8.4 after treatment; t = 3.03, 5DF, p = 0.02, two-tailed paired t-test). Two subjects showed robust mood improvement which occurred progressively over the course of several weeks. In one subject, depression symptoms completely remitted for the first time in 3 years. Daily left prefrontal rTMS appears to be safe, well tolerated and may alleviate depression.