Relation of serum adiponectin levels and obesity with breast cancer: a Japanese case-control study.
Relation of serum adiponectin levels and obesity with breast cancer: a Japanese case-control study.
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DOI：
10.7314/apjcp.2014.15.19.8325
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发表时间：
2014-10
期刊：
影响因子：
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通讯作者：
Machiko Minatoya;G. Kutomi;H. Shima;Sumiyo Asakura;S. Otokozawa;Hirofumi Ohnishi;H. Akasaka;T. Miura;M. Mori;K. Hirata
中科院分区：
文献类型：
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作者：
Machiko Minatoya;G. Kutomi;H. Shima;Sumiyo Asakura;S. Otokozawa;Hirofumi Ohnishi;H. Akasaka;T. Miura;M. Mori;K. Hirata
背景技术众所周知，肥胖是乳腺癌的危险因素之一，尽管这种关联在种族群体之间以及与绝经状态之间可能有所不同。最近，人们对肥胖相关的危险因素（包括血清脂联素和胰岛素水平）以及体重指数（BMI）与乳腺癌风险的关系进行了分析。材料和方法 我们在一项基于医院的病例对照研究中测量了血清高分子量 (HMW) 脂联素和胰岛素水平，该研究包括 66 组日本女性乳腺癌病例以及年龄和绝经状态匹配的对照。研究人员检查了 HMW 脂联素的血清水平、胰岛素水平和体重指数 (BMI) 与乳腺癌风险的关系，并根据绝经状态调整了各种已知的风险因素。结果 HMW 脂联素水平最高的女性绝经前和绝经后女性患乳腺癌的风险均显着降低（比值比 (OR) 为 0.01；95% 置信区间 (CI) 分别为 0.00-0.26 和 0.13；0.03-0.57）。 BMI 较低表明绝经前和绝经后女性患乳腺癌的风险均降低（OR，0.04；95% CI，0.00-0.69；OR，0.28；95% CI，0.07-1.11）。结论 这些结果表明，日本绝经前和绝经后女性中较高的血清 HMW 脂联素水平和较低的 BMI 与乳腺癌风险降低相关，为肥胖之间的联系提供了证据。
BACKGROUND It is known that obesity is one of the risk factors for breast cancer although the association may differ between ethnic groups and with the menopausal status. Recently obesity-related risk factors including serum adiponectin and insulin levels have been analyzed together with BMI in association with breast cancer risk. MATERIALS AND METHODS We measured serum high molecular weight (HMW) adiponectin and insulin levels in a hospital based case-control study, including 66 sets of Japanese female breast cancer cases and age and menopausal status matched controls. Serum levels of HMW adiponectin, insulin levels and body mass index (BMI) were examined in association with breast cancer risk with adjustment for the various known risk factors by menopausal status. RESULTS Women in the highest HMW adiponectin levels showed significant reduced risk of breast cancer in both pre and postmenopausal women (odds ratio (OR), 0.01; 95% confidence interval (CI), 0.00-0.26 and 0.13; 0.03-0.57, respectively). Lower BMI showed decreased breast cancer risk in both pre and postmenopausal women (OR, 0.04; 95% CI, 0.00-0.69, OR, 0.28; 95% CI, 0.07-1.11, respectively). CONCLUSIONS These results indicated that higher serum HMW adiponectin levels and lower BMI are associated with a decreased breast cancer risk in both pre and postmenopausal women in Japan, adding evidence for the obesity link.