NONRANDOM CHROMOSOME CHANGES IN CARCINOMA OF THE CERVIX UTERI .2. 10 TUMORS IN THE TRIPLOID TETRAPLOID RANGE
NONRANDOM CHROMOSOME CHANGES IN CARCINOMA OF THE CERVIX UTERI .2. 10 TUMORS IN THE TRIPLOID TETRAPLOID RANGE
复制标题
DOI：
10.1016/0165-4608(84)90043-8
复制
发表时间：
1984-01-01
影响因子：
--
通讯作者：
BAKER, MC
中科院分区：
文献类型：
--
作者：
ATKIN, NB;BAKER, MC
10例模式数在60-82之间的宫颈癌直接制片中的非随机染色体变化与以前对近二倍体肿瘤的研究中发现的相似：1号染色体(7个肿瘤)和11号染色体(5个肿瘤)最常参与结构重排，6个肿瘤中可见小的中着丝粒，常呈重复出现。小中部着丝粒的出现再次提示起源于4号或5号染色体：长臂缺失或短臂等位染色体；在1个肿瘤中，Giemsa-11显带与#4比#5更相容。4个肿瘤可能存在17号染色体异常，2个肿瘤有标记，可能来自2号染色体，含有均匀染色的区域。
Nonrandom chromosome changes in direct preparations of 10 [human] cervical carcinomas with modal numbers in the range of 60-82 were similar to those found in a previous study on near-diploid tumors: Chromosomes 1 (7 tumors) and 11 (5 tumors) were most often involved in structural rearrangements and a small metacentric, often present in duplicate, was seen in 6 tumors. The appearances of the small metacentric again suggested an origin from a chromosome #4 or #5: either a long arm deletion or a short arm isochromosome; in 1 tumor, Giemsa-11 banding was more compatible with a #4 than a #5. Chromosome #17 anomalies were probably present in 4 tumors and 2 tumors had markers, probably derived from chromosome #2, containing homogeneously staining regions.