Forskolin, a potent adenylate cyclase activator, lowers rabbit intraocular pressure.
Forskolin, a potent adenylate cyclase activator, lowers rabbit intraocular pressure.
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Forskolin 是一种有效的腺苷酸环化酶激活剂，可降低兔眼压。
DOI：
10.1001/archopht.1984.01040030124051
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发表时间：
1984
影响因子：
--
通讯作者：
L. Zeleznick
中科院分区：
文献类型：
--
作者：
B. R. Smith;R. Gaster;I. Leopold;L. Zeleznick
据我们所知，这是第一个局部应用，特异性腺苷酸环化酶激活剂，降低眼内压的报告。毛喉素是一种新型的腺苷酸环化酶激活剂，据报道，在完整的细胞中增加环磷酸腺苷（AMP）。环磷酸腺苷水平增加与各种抗青光眼药物。0.1%和0.05%两种浓度的毛喉素可显著降低兔眼内压。高眼压发生率分别为0.05%和0.2%。使用0.01%毛喉素时未观察到IOP变化。用0.1%和0.05%毛喉素降低IOP持续约6小时。在降低IOP的剂量中观察到轻度、一过性结膜水肿。对侧对照眼显示IOP降低，但通过Student配对t检验，对照眼和测试眼之间的差异是显著的。
To our knowledge, this is the first report of a topically applied, specific adenylate cyclase activator that reduces intraocular pressure. Forskolin, a novel adenylate cyclase activator, is reported to increase cyclic adenosine monophosphate (AMP) in intact cells. Cyclic AMP levels are increased with various antiglaucoma agents. Intraocular pressure in rabbits was significantly reduced with two concentrations of forskolin, 0.1% and 0.05%. Ocular hypertension was noted with 0.05% and 0.2%. No change in IOP was noted with 0.01% forskolin. The IOP lowering with 0.1% and 0.05% forskolin lasted approximately six hours. Mild, transient conjunctival chemosis was noted in the doses that decreased IOP. The contralateral control eye showed decreases in IOP, but the differences between control and tested eyes were significant by the Student's paired t test.
影响因子：
4.4
作者：
Gregory,D;Sears,M;Bausher,L;Mishima,H;Mead,A
通讯作者：
Mead,A