BIOACTIVE MARINE METABOLITES .48. CINACHYROLIDE-A - A POTENT CYTOTOXIC MACROLIDE POSSESSING 2 SPIRO KETALS FROM MARINE SPONGE CINACHYRA SP
BIOACTIVE MARINE METABOLITES .48. CINACHYROLIDE-A - A POTENT CYTOTOXIC MACROLIDE POSSESSING 2 SPIRO KETALS FROM MARINE SPONGE CINACHYRA SP
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DOI：
10.1021/ja00063a017
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发表时间：
1993-05-19
影响因子：
15
通讯作者：
MATSUNAGA, S
中科院分区：
文献类型：
--
作者：
FUSETANI, N;SHIMODA, K;MATSUNAGA, S
从海绵Cinachyra sp.中分离到一种具有高细胞毒性的大环内酯，cinachyrolide A。在noesi数据的基础上，提出了六氧环的相对立体化学。
A highly cytotoxic macrolide, cinachyrolide A, has been isolated from marine sponge Cinachyra sp. The gross structure was determined mainly by extensive 2D NMR experiments. The relative stereochemistry of the six oxane rings is proposed on the basis of NOESY data.