Respiratory Outcomes in Patients Following COVID-19-Related Hospitalization: A Meta-Analysis.
Respiratory Outcomes in Patients Following COVID-19-Related Hospitalization: A Meta-Analysis.
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DOI：
10.3389/fmolb.2021.750558
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发表时间：
2021
影响因子：
5
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Guo T;Jiang F;Liu Y;Zhao Y;Li Y;Wang Y
背景：确定COVID-19相关住院患者的呼吸结局。 方法：对文献进行系统回顾和荟萃分析。 结果如下：用力肺活量（FVC，占预测值的%）：出院后0-3个月：96.1，95% CI [82.1-110.0];出院后3-6个月：99.9，95% CI [84.8，115.0];出院后>6个月：97.4，95% CI [76.8-118.0]。肺一氧化碳弥散量（DLCO，预测值的%）：出院后0-3个月：83.9，95% CI [68.9-98.9];出院后3-6个月：91.2，95% CI [74.8-107.7];出院后>6个月：97.3，95% CI [76.7-117.9]。FVC低于预测值80%的患者百分比：出院后0-3个月：10%，95% CI [6-14%];出院后3-6个月：10%，95% CI [2-18%];出院后>6个月：13%，95% CI [8-18%]。DLCO低于预测值80%的患者百分比：出院后0-3个月：48%，95% CI [41-56%];出院后3-6个月：33%，95% CI [23-44%];出院后>6个月：43%，95% CI [22-65%]。 结论：荟萃分析证实，COVID-19相关住院患者中持续性肺弥散功能障碍的患病率较高。因此，强烈建议进行常规呼吸随访。
Background: To determine the respiratory outcomes in patients following COVID-19-related hospitalization. Methods: Systematic review and meta-analysis of the literature. Results: Forced vital capacity (FVC, % of predicted): 0–3 months post discharge: 96.1, 95% CI [82.1–110.0]; 3–6 months post discharge: 99.9, 95% CI [84.8, 115.0]; >6 months post discharge: 97.4, 95% CI [76.8–118.0]. Diffusing capacity of the lungs for carbon monoxide (DLCO, % of predicted): 0–3 months post discharge: 83.9, 95% CI [68.9–98.9]; 3–6 months post discharge: 91.2, 95% CI [74.8–107.7]; >6 months post discharge: 97.3, 95% CI [76.7–117.9]. Percentage of patients with FVC less than 80% of predicted: 0–3 months post discharge: 10%, 95% CI [6–14%]; 3–6 months post discharge: 10%, 95% CI [2–18%]; >6 months post discharge: 13%, 95% CI [8–18%]. Percentage of patients with DLCO less than 80% of predicted: 0–3 months post discharge: 48%, 95% CI [41–56%]; 3–6 months post discharge: 33%, 95% CI [23–44%]; >6 months post discharge: 43%, 95% CI [22–65%]. Conclusion: The meta-analysis confirms a high prevalence of persistent lung diffusion impairment in patients following COVID-19-related hospitalization. Routine respiratory follow-up is thus strongly recommended.