Early postnatal blood concentrations of inflammation-related proteins and microcephaly two years later in infants born before the 28th post-menstrual week
Early postnatal blood concentrations of inflammation-related proteins and microcephaly two years later in infants born before the 28th post-menstrual week
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DOI：
10.1016/j.earlhumdev.2011.01.043
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发表时间：
2011-05-01
影响因子：
2.5
通讯作者：
Paneth, Nigel
中科院分区：
文献类型：
--
作者：
Leviton, Alan;Kuban, Karl C. K.;Paneth, Nigel
背景：评估两年后小头早产新生儿早期产后血液标本中炎症相关蛋白浓度是否升高。方法：我们从839名妊娠28周前出生的婴儿中采集血液，分别在第1、7和14天采集25种蛋白质，这些婴儿在出生时和产后近24个月时测量头围。我们排除出生时头围等于或低于第三百分位的儿童。蛋白质浓度被认为是升高，如果它是在胎龄最高的四分位数和当天获得标本。结果：当单独评估蛋白质时，第1天SAA和第14天5种蛋白质、IL-6、TNF-R2、IL-8、MCP-1和ICAM-1的浓度升高与小头畸形的风险显著增加相关（头围z评分< -2）。有10种蛋白的浓度在一周中的两天升高可以预测小头畸形，但在其中一天升高则不能预测小头畸形，这10种蛋白分别是CRP、SAA、IL-1 β、IL-6、tnf - α、IL-8、MCP-1、ICAM-1、E-SEL、IGFBP-1。升高的蛋白浓度弱预测头围减少程度较轻（Z-score >= -2, < -1）。解释：早产后不久血液循环中炎症相关蛋白的浓度提供了两年后头围减小风险的信息。资金：ELGAN研究得到了与美国国家神经疾病和中风研究所的合作协议的支持。2011爱思唯尔爱尔兰有限公司版权所有。
Background: To evaluate if concentrations of inflammation-related proteins were elevated in early postnatal blood specimens of preterm newborns who two years later had a small head.Methods: We measured 25 proteins in blood collected on days 1, 7, and 14 from 839 infants born before the 28th week of gestation and whose head circumference was measured at birth and near 24-months post-term equivalent. We excluded children whose birth head circumference was at or below the third centile. A protein concentration was considered elevated if it was in the highest quartile for gestational age and the day the specimen was obtained.Findings: When proteins were evaluated individually, elevated concentrations of SAA on day 1 and five proteins on day 14, IL-6, TNF-R2, IL-8, MCP-1, and ICAM-1 were associated with significantly increased risk of microcephaly (head circumference Z-score < -2). The ten proteins whose elevated concentrations on two separate days a week apart predicted microcephaly, but did not do so when elevated on only one of these days were CRP, SAA, IL-1 beta, IL-6, TNF-alpha, IL-8, MCP-1, ICAM-1, E-SEL, IGFBP-1. Elevated protein concentrations weakly predicted a less severe reduction in head circumference (Z-score >= -2, < -1).Interpretation: Concentrations of inflammation-related proteins in the circulation shortly after preterm birth provide information about the risk of a reduced head circumference more than two years later.Funding: The ELGAN Study was supported by a cooperative agreement with the National Institute of Neurological Disorders and Stroke of the United States. (C) 2011 Elsevier Ireland Ltd. All rights reserved.