Place conditioning in a three- or four-choice apparatus: role of stimulus novelty in drug-induced place conditioning.
Place conditioning in a three- or four-choice apparatus: role of stimulus novelty in drug-induced place conditioning.
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在三或四选择装置中进行位置调节：刺激新颖性在药物诱导的位置调节中的作用。
DOI：
10.1037//0735-7044.106.2.294
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发表时间：
1992
影响因子：
1.9
通讯作者：
Parker,LA
中科院分区：
文献类型：
--
作者：
Parker,LA
在一系列 4 项实验中进行了检查，结果表明（MT Scoles 和 S. Siegel，1986）药物引起的位置偏好调节可能是由于习惯化的干扰造成的。在每个实验中，大鼠有机会在药物配对室、盐水配对室和新颖（或相对新颖）的室中进行选择。这些药物包括积极增强药物安非他明、阿扑吗啡、吗啡和尼古丁以及厌恶药物氯化锂。与新的房间相比，老鼠更喜欢与安非他明、阿朴吗啡和吗啡配对的房间。然而，他们也始终更喜欢新颖的腔室而不是熟悉的盐水配对腔室。没有证据表明尼古丁具有调节作用。在 3 选择装置中进行单次调节试验后，会出现药物引起的位置偏好，但不会出现新奇偏好，而在 4 选择装置中则不会。经过 1-3 次条件反射试验后，氯化锂产生了位置厌恶。活动测量显示，大鼠在最喜欢的房间中最不活跃，而在最不喜欢的房间中最活跃。（PsycINFO 数据库记录 (c) 2016 APA，保留所有权利）
Examined in a series of 4 experiments the suggestion (MT Scoles and S. Siegel, 1986) that drug-induced place preference conditioning may be due to interference with habituation. In each experiment, rats had the opportunity to select among a drug-paired chamber, a saline-paired chamber, and a novel (or relatively novel) chamber. The drugs included the positively reinforcing drugs amphetamine, apomorphine, morphine, and nicotine and the aversive drug lithium chloride. The rats preferred chambers that were paired with amphetamine, apomorphine, and morphine more than chambers that were novel; however, they also consistently preferred novel chambers to familiar saline-paired chambers. There was no evidence of place conditioning with nicotine. The drug-induced place preference, but not the novelty preference, occurred after a single conditioning trial in a 3-choice apparatus but not a 4-choice apparatus. Lithium chloride established a place aversion after 1–3 conditioning trials. Measures of activity revealed that the rats were least active while in their most preferred chamber and most active while in their least preferred chamber.(PsycINFO Database Record (c) 2016 APA, all rights reserved)