Synthesis of Pyrido[2,3-c]coumarin Derivatives by an Intramolecular Povarov Reaction
Synthesis of Pyrido[2,3-c]coumarin Derivatives by an Intramolecular Povarov Reaction
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DOI：
10.1055/s-0034-1380131
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发表时间：
2015-04-01
影响因子：
2.6
通讯作者：
Khan, Abu T.
中科院分区：
文献类型：
--
作者：
Belal, Md.;Das, Deb K.;Khan, Abu T.
在乙腈中，10mol%三氟甲磺酸催化下，2-（丙氧基）苯甲醛与3-氨基香豆素发生分子内Povarov反应，合成了稠合吡啶并[2，3-c]香豆素衍生物.该方案的优点之一是反应时间较短，产率高，不需要水处理和色谱分离。
Fused pyrido[2,3-c]coumarin derivatives were prepared by an intramolecular Povarov reaction of 2-(propagyloxy)benzaldehydes with 3-aminocoumarins in the presence of 10 mol% of triflic acid as a catalyst in refluxing acetonitrile. Among the advantages of this protocol are shorter reaction times, good yields, and the absence of the need for aqueous workup and chromatographic separation.