Impact of implementing French antibiotic guidelines for acute respiratory-tract infections in a paediatric emergency department, 2005-2009
Impact of implementing French antibiotic guidelines for acute respiratory-tract infections in a paediatric emergency department, 2005-2009
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DOI：
10.1007/s10096-011-1442-4
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发表时间：
2012-07-01
影响因子：
4.5
通讯作者：
Alberti, C.
中科院分区：
文献类型：
--
作者：
Angoulvant, F.;Skurnik, D.;Alberti, C.
急性呼吸道感染（ARTIs）是儿童使用抗生素的主要原因。2005年，法国药品管理局发布了指南，以尽量减少ARTI中抗生素的不当使用。本研究的目的是评估在儿科急诊科实施这些指南的影响。我们回顾性分析了2005年11月（指南实施日期）至2009年10月在法国儿科急诊科前瞻性收集的数据。对于每个被诊断为ARTI的儿童，我们收集了年龄、诊断和处方抗生素。我们计算了研究人群的抗生素处方率。在研究期间，53055名儿童被诊断为ARTI，出院时开出的22198张抗生素处方中有59%与ARTI有关。ARTI患者服用抗生素处方的比例从第一年的32.1%下降到第四年的21% （p < 10(-4)， Cochran-Armitage检验）。阿莫西林-克拉维酸和阿莫西林分别占ARTI抗生素处方的50%和34%。法国抗生素指南导致我们儿科急诊科ARTI抗生素处方显著减少。
Acute respiratory tract infections (ARTIs) are the main reason for antibiotic prescription in children. In 2005, the French Drug Agency published guidelines to minimise inappropriate use of antibiotics for ARTI. The purpose of this study was to assess the impact of implementing these guidelines in a paediatric emergency department. We retrospectively analysed data collected prospectively in a French paediatric emergency department from November 2005 (date of guideline implementation) to October 2009. For each child diagnosed with ARTI, we collected age, diagnosis, and prescribed antibiotics. We computed antibiotic prescription rates in the study population. During the study period, 53,055 children were diagnosed with ARTI and 59% of the 22,198 antibiotic prescriptions given at discharge were related to ARTI. The proportion of ARTI patients given antibiotic prescriptions fell from 32.1% during the first year to 21% in year 4 (p < 10(-4), Cochran-Armitage test). Amoxicillin-clavulanic acid and amoxicillin accounted for 50% and 34% of antibiotic prescriptions for ARTI, respectively. French antibiotic guidelines led to significant decreases in antibiotic prescription for ARTI in our paediatric emergency department.