Delta Opioid Receptors and Modulation of Mood and Emotion
Delta Opioid Receptors and Modulation of Mood and Emotion
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DOI：
10.1007/164_2017_42
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Jutkiewicz, Emily M.
中科院分区：
文献类型：
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作者：
Dripps, Isaac J.;Jutkiewicz, Emily M.
抑郁症是一种普遍存在的、使人衰弱的精神障碍，在大多数患者中，目前的药物疗法对其治疗不足。虽然阿片类药物长期以来一直被认为可以调节情绪状态，但很少讨论使用阿片类药物治疗抑郁症。本章探讨了支持阿片配体，特别是δ阿片受体（DOR）激动剂的抗抑郁样作用的临床前和临床证据。DOR激动剂已显示在许多动物模型中产生抗抑郁样作用。一些DOR激动剂也产生惊厥，这限制了它们的临床应用。然而，DOR激动剂，产生抗抑郁样作用，没有惊厥最近已经开发出来，这些药物开始在人类中进行评估。还探讨了DOR激动剂抗抑郁样作用的潜在作用机制。了解导致DOR介导行为的机制对于开发具有更高安全性和临床实用性的DOR药物至关重要，未来的工作应致力于阐明这些途径。
Depression is a pervasive and debilitating mental disorder that is inadequately treated by current pharmacotherapies in a majority of patients. Although opioids have long been known to regulate mood states, the use of opioids to treat depression is rarely discussed. This chapter explores the preclinical and clinical evidence supporting the antidepressant-like effects of opioid ligands, and in particular, delta opioid receptor (DOR) agonists. DOR agonists have been shown to produce antidepressant-like effects in a number of animal models. Some DOR agonists also produce convulsions which has limited their clinical utility. However, DOR agonists that generate antidepressant-like effects without convulsions have recently been developed and these drugs are beginning to be evaluated in humans. Work investigating potential mechanisms of action for the antidepressant-like effects of DOR agonists is also explored. Understanding mechanisms that give rise to DOR-mediated behaviors is critical for the development of DOR drugs with improved safety and clinical utility, and future work should be devoted to elucidating these pathways.