Tumour Cell Heterogeneity.
Tumour Cell Heterogeneity.
复制标题
DOI：
10.12688/f1000research.7210.1
复制
发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Graham, Trevor A
中科院分区：
文献类型：
--
作者：
Gay, Laura;Baker, Ann-Marie;Graham, Trevor A
构成癌症的细胞群在遗传、表观遗传和表型水平上明显具有异质性。在这篇小型综述中，我们总结了人类恶性肿瘤中肿瘤内异质性 (ITH) 的程度，回顾了产生和维持 ITH 的机制，并讨论了 ITH 对癌症预测和治疗的影响和机会。
The population of cells that make up a cancer are manifestly heterogeneous at the genetic, epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human malignancies, review the mechanisms that are responsible for generating and maintaining ITH, and discuss the ramifications and opportunities that ITH presents for cancer prognostication and treatment.