Post-elution processing of 44Ti/44Sc generator-derived 44Sc for clinical application
Post-elution processing of 44Ti/44Sc generator-derived 44Sc for clinical application
复制标题
DOI：
10.1016/j.apradiso.2010.04.003
复制
发表时间：
2010-09-01
影响因子：
1.6
通讯作者：
Roesch, F.
中科院分区：
文献类型：
--
作者：
Pruszynski, M.;Loktionova, N. S.;Roesch, F.
Ti-44/Sc-44（T-1/2 Ti-44 =60 a）发生器提供了用于PET成像的正电子发射Sc-44（T-1/2=3.97 d）的回旋加速器独立访问。本工作旨在对初始Sc-44发生器洗脱液进行后洗脱处理，以减少其体积、HCl浓度并去除草酸根阴离子。阳离子树脂AG 50 W-X8（200-400目，H+型）对~（44）Sc的在线吸附率大于98%。然后用3 ml 0.25 M醋酸铵（pH = 4.0）解吸纯化后的Sc-44，后处理时间为10 min，后处理的总收率达到90%，以Ti-44/Sc-44发生器得到的Sc-44计。除化学纯化外，Ti-44穿透的含量进一步降低了一个数量级。185 MBq发生器最终提供150 MBq的Sc-44，
The Ti-44/Sc-44 (T-1/2 Ti-44 =60 a) generator provides cyclotron-independent access to positron-emitting Sc-44 (T-1/2=3.97 d) for PET imaging. This work aims to post-elution processing of initial Sc-44 generator eluates in order to reduce its volume, HCI concentration and remove the oxalate anions. The on-line adsorption of 44Sc on cationic resin AG 50W-X8 (200-400 mesh, H+-form) is achieved with > 98% efficacy. Subsequently, the purified Sc-44 is desorbed by using 3 ml of 0.25 M ammonium acetate (pH =.4.0).The post-processing takes 10 min. The overall yield of the post-processing reached 90%, which is referred to the Sc-44 obtained from the Ti-44/Sc-44 generator. In addition to the chemical purification, the content of Ti-44 breakthrough was further reduced by one order of magnitude. The 185 MBq generator finally provides 150 MBq of Sc-44 containing