Age does not affect basal gastric acid secretion in normal subjects or in patients with acid-peptic disease.
Age does not affect basal gastric acid secretion in normal subjects or in patients with acid-peptic disease.
复制标题
年龄不影响正常受试者或胃酸消化病患者的基础胃酸分泌。
DOI：
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发表时间：
1994
影响因子：
9.8
通讯作者：
Yang K. Chen
中科院分区：
文献类型：
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作者：
Collen Mj;Abdulian Jd;Yang K. Chen
目标
确定基础酸排出量是否受患者年龄的影响。
方法
在正常受试者 (n = 65) 和患有胃食管反流病 (n = 228)、胃溃疡 (n = 81)、十二指肠溃疡 (n = 184) 和非溃疡性消化不良 (n = 105) 的患者中前瞻性评估了通过鼻胃抽吸确定的基础酸排出量。
结果
正常人和胃食管反流病、胃溃疡、十二指肠溃疡和非溃疡性消化不良患者的基础酸排出量与年龄没有相关性。然而，33 名男性胃溃疡患者（r = -0.41，p < 0.05）和 130 名男性十二指肠溃疡患者（r = -0.18，p = 0.05）的年龄和基础酸排出量之间存在显着的负相关。此外，患有胃食管反流病（p < 0.001）、胃溃疡（p < 0.05）和十二指肠溃疡（p < 0.001）的男性患者的平均基础酸排出量显着高于女性患者。 184 名十二指肠溃疡患者的平均基础酸排出量显着高于 228 名胃食管反流病患者的平均基础酸排出量（p < 0.001），并且均显着高于正常受试者以及胃溃疡和非溃疡性消化不良患者的平均基础酸排出量（p < 0.0005）。
结论
基础酸排出量可能因性别和酸性消化病过程而异；然而，基础酸输出不随受试者年龄的变化而变化。
OBJECTIVES
To determine whether basal acid output was affected by patient age.
METHODS
Basal acid output determined by nasogastric suction was prospectively evaluated in normal subjects (n = 65) and patients with gastroesophageal reflux disease (n = 228), gastric ulcer (n = 81), duodenal ulcer (n = 184), and nonulcer dyspepsia (n = 105).
RESULTS
There was no correlation between basal acid output and age for the normal subjects and the patients with gastroesophageal reflux disease, gastric ulcer, duodenal ulcer, and nonulcer dyspepsia. However, there was a significant inverse correlation between age and basal acid output for the 33 male patients with gastric ulcer (r = -0.41, p < 0.05) and the 130 male patients with duodenal ulcer (r = -0.18, p = 0.05). Furthermore, mean basal acid outputs were significantly higher for male patients than for female patients with gastroesophageal reflux disease (p < 0.001), gastric ulcer (p < 0.05), and duodenal ulcer (p < 0.001). Mean basal acid output for the 184 patients with duodenal ulcer was significantly higher than the mean basal acid output for the 228 patients with gastroesophageal reflux disease (p < 0.001), and both were significantly higher than mean basal acid outputs for the normal subjects and the patients with gastric ulcer and nonulcer dyspepsia (p < 0.0005).
CONCLUSIONS
Basal acid output can vary with gender and acid-peptic disease process; however, basal acid output does not vary with regard to age of subject.