Utility of the Boston Naming Test in predicting ultimate side of surgery in patients with medically intractable temporal lobe epilepsy
Utility of the Boston Naming Test in predicting ultimate side of surgery in patients with medically intractable temporal lobe epilepsy
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DOI：
10.1111/j.1528-1167.2005.00300.x
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发表时间：
2005-11-01
期刊：
影响因子：
5.6
通讯作者：
Kubu, CS
中科院分区：
文献类型：
--
作者：
Busch, RM;Frazier, TW;Kubu, CS
目的：对抗命名任务一直被认为是敏感的左颞叶功能障碍，因此，经常用于评估手术癫痫患者。尽管这种方法被广泛而频繁地使用，但很少有研究探讨对抗命名任务在颞叶癫痫（TLE）患者中的应用。方法：本研究检测了217例难治性右利手TLE成人患者的术前波士顿认知测验（BNT）表现（左，108;右，109），以确定该措施在预测手术最终侧的效用。结果支持BNT在确定手术最终侧的临床效用，并表明BNT在术前延迟记忆和智力评分之上具有增量有效性。这种关系被认为是由全量表智商（FSIQ），癫痫发作时的年龄，癫痫持续时间。使用逻辑回归方程预测手术侧显示，在BNT评分低、FSIQ高和癫痫发作年龄晚的患者中，左颞叶手术的预测效果最好。与此相反，右颞手术是最好的预测BNT分数高，低FSIQs，和癫痫持续时间短的患者。结论：这项研究支持的临床效用的BNT在术前评估的候选人TLE手术，并强调了检查潜在的调节变量时，对手术侧的预测的重要性。本研究进一步为临床医生提供了一个回归方程，可用于预测颞叶癫痫患者的手术侧。
Purpose: Confrontation naming tasks have long been presumed to be sensitive to left temporal dysfunction and, consequently, are frequently used in the evaluation of surgical epilepsy patients. Despite wide and frequent use, few studies have examined the utility of confrontation naming tasks in individuals with temporal lobe epilepsy (TLE).Methods: The current study examined the presurgical Boston Naming Test (BNT) performance of 217 right-handed adult patients with intractable TLE (left, 108; right, 109) to determine the utility of this measure in predicting ultimate side of surgery.Results: The results support the clinical utility of the BNT in determining ultimate side of surgery and suggest that the BNT has incremental validity over and above presurgical delayed memory and intelligence scores. This relation was found to be moderated by Full Scale IQ (FSIQ), age at seizure onset, and duration of epilepsy. The use of a logistic regression equation to predict side of surgery revealed that prediction of left temporal surgery was best among patients with low BNT scores, high FSIQs, and late age at seizure onset. In contrast, right temporal surgery was best predicted among patients with high BNT scores, low FSIQs, and short duration of epilepsy.Conclusions: This study supports the clinical utility of the BNT in the preoperative evaluation of candidates for TLE surgery and highlights the importance of examining potential moderating variables when making predictions about side of surgery. This study further provides clinicians with a regression equation that can be used to predict side of surgery in patients with temporal lobe epilepsy.