Studies on heterologous anti-lymphocyte serum in mice. II. Effect on the immune response.
Studies on heterologous anti-lymphocyte serum in mice. II. Effect on the immune response.
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DOI：
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发表时间：
1966-02
影响因子：
4.4
通讯作者：
A. Monaco;M. Wood;J. Gray;P. Russell
中科院分区：
文献类型：
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作者：
A. Monaco;M. Wood;J. Gray;P. Russell
1.兔抗A/Jax淋巴细胞血清（RAMLS）给A/Jax小鼠抑制初级和在一定程度上，次级血凝素反应绵羊红细胞。2. RAMLS处理的小鼠显示出排斥第一和第二组皮肤同种异体移植物和大鼠皮肤异种移植物的能力降低。3. RAMLS延长同种异体皮肤移植物的时间可能是由于对同种异体排斥反应的中枢抑制。4.从RAMLS中提取的粗γ-球蛋白组分在抑制同种异体移植反应方面与全血清一样有效。5. RAMLS抑制同种异体移植排斥反应的能力不是由于RAMLS中存在的小鼠γ-球蛋白抗体。6. RAMLS是诱导淋巴细胞耗竭状态的有效生物试剂。
1. Rabbit anti-A/Jax lymphocyte serum (RAMLS) given to A/Jax mice inhibits the primary and, to some extent, the secondary hemagglutinin response to sheep erythrocytes. 2. RAMLS-treated mice show decreased ability to reject first and second set skin allografts and rat skin xenografts. 3. Prolongation of skin allografts by RAMLS is probably due to a central inhibition of the allograft rejection response. 4. The crude γ-globulin fraction extracted from RAMLS is as effective in inhibiting the allograft response as the whole serum. 5. The ability of RAMLS to inhibit the allograft rejection response is not due to the antibodies to mouse γ-globulin present in the RAMLS. 6. RAMLS is a potent biologic reagent for the induction of states of lymphocyte depletion.