Research Progress on B Cells and Thoracic Aortic Aneurysm/Dissection
Research Progress on B Cells and Thoracic Aortic Aneurysm/Dissection
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B细胞与胸主动脉瘤/夹层的研究进展
DOI：
10.1016/j.avsg.2021.11.018
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发表时间：
2022-05-05
影响因子：
1.5
通讯作者：
Xia, Wei
中科院分区：
文献类型：
--
作者：
Hou, Yue;Li, Yan;Xia, Wei
胸主动脉瘤/夹层（TAAD）是一种罕见的心血管疾病，其特点是起病急、进展快、发病率和死亡率高。导致TAAD的关键因素之一是炎症反应，该反应受到许多免疫细胞亚群（包括B细胞）的调节。与正常主动脉组织相比，TAAD患者主动脉组织中B细胞数量明显增多。活化的B细胞通过产生抗体和炎性因子并活化补体系统参与血管免疫炎症反应。这些影响可导致胶原降解和主动脉壁重塑，这两者都是TAAD的主要病理特征。因此，B细胞在TAAD的发生发展中起着关键作用。B细胞可分为B1细胞、B2细胞和调节性B细胞，它们在TAAD中具有不同的作用机制。本文将从B细胞的三种不同亚型的角度对B细胞在TAAD中的作用进行综述。
Thoracic aortic aneurysm/dissection (TAAD) is a rare cardiovascular disease characterized by acute onset, rapid progression and high morbidity and mortality. One of the crucial factors leading to TAAD is the inflammatory response, which is regulated by many immune cell subgroups, including B cells. Compared with normal aortic tissue, the number of B cells in the aortic tissue of TAAD patients is significantly higher. Activated B cells participate in the vascular immune inflammatory response by producing antibodies and inflammatory factors and activating the complement system. These effects can lead to collagen degradation and aortic wall remodeling, both of which are the main pathologic characteristics of TAAD. Therefore, B cells play a key role in the occurrence and development of TAAD. B cells can be divided into B1 cells, B2 cells and regulatory B cells, which have different mechanisms of action in TAAD. This article will review the role of B cells in TAAD from the perspective of three different subtypes of B cells.