Small GTPases modulate intrinsic and extrinsic forces that control epithelial folding in Drosophila embryos.
Small GTPases modulate intrinsic and extrinsic forces that control epithelial folding in Drosophila embryos.
复制标题
小 GTP 酶调节控制果蝇胚胎中上皮折叠的内在和外在力。
DOI：
10.1080/21541248.2021.1926879
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Glotzer,Michael
中科院分区：
文献类型：
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作者：
Rich,Ashley;Glotzer,Michael
上皮折叠是执行形态发生运动的常见手段。原肠胚形成的果蝇胚胎提供了许多上皮折叠事件的例子，包括腹沟、头沟和背沟。这些折叠事件中的每一个都与自主促进上皮折叠的细胞内收缩性和/或细胞骨架结构的变化相关。在这里，我们回顾积累的证据表明，腹，头，背沟的进展和最终形式也受到这些褶皱附近的细胞的行为。我们进一步讨论了上皮折叠事件中交界重排的发生率和重要性，表明粘附连接组件是调节影响折叠事件的细胞间力传输的主要候选者。最后，我们讨论了最近开发的方法，使精确的空间和/或时间控制蛋白质活性允许直接测试的分子模型的形态发生在体内。
Epithelial folding is a common means to execute morphogenetic movements. The gastrulating Drosophila embryo offers many examples of epithelial folding events, including the ventral, cephalic, and dorsal furrows. Each of these folding events is associated with changes in intracellular contractility and/or cytoskeleton structures that autonomously promote epithelial folding. Here, we review accumulating evidence that suggests the progression and final form of ventral, cephalic, and dorsal furrows are also influenced by the behaviour of cells neighbouring these folds. We further discuss the prevalence and importance of junctional rearrangements during epithelial folding events, suggesting adherens junction components are prime candidates to modulate the transmission of the intercellular forces that influence folding events. Finally, we discuss how recently developed methods that enable precise spatial and/or temporal control of protein activity allow direct testing of molecular models of morphogenesis in vivo.