Heat shock proteins as vaccine candidates.
Heat shock proteins as vaccine candidates.
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热休克蛋白作为候选疫苗。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
Newport Gr
中科院分区：
文献类型：
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作者：
Newport Gr
寄生虫热休克蛋白是一种在遗传学上高度保守的抗原嵌合体，但在感染过程中可刺激体液和细胞免疫应答。这些范围从高度特异性到广泛的交叉反应，中间程度也有记录。后者可能证明是有益的，如果它们可以适当地引导以防止多种病原体，或可能有害的，如果它们与宿主成分交叉反应。因此，评估热休克蛋白作为疫苗候选人进行了谨慎的，正在努力映射宿主免疫反应的特异性的分子的单个表位。最终，为了用作疫苗，所述分子必须在活病原体的背景下被免疫系统识别，并且能够诱导适当的细胞和/或体液免疫应答，所述细胞和/或体液免疫应答有效地防止单个病原体的建立。综述了寄生虫热休克蛋白作为疫苗成分的相关研究，重点是来自疟原虫、疟疾、衣原体和分枝杆菌寄生虫的热休克蛋白。
Parasite heat shock proteins are phylogenetically well-conserved antigenic mosaics that nonetheless stimulate both humoral and cellular immune responses during the course of infection. These range from highly specific to broadly cross-reactive, with intermediate degrees also documented. The latter may prove beneficial, if they can be appropriately channelled to protect against multiple pathogens, or potentially harmful, if they cross-react with host components. Assessment of heat shock proteins as vaccine candidates has thus proceeded cautiously, with efforts being made to map the specificity of host immune responses to individual epitopes of the molecules. Ultimately, to serve as vaccines, the molecules must be recognized by the immune system within the context of a living pathogen, and be capable of inducing appropriate cellular and/or humoral immune responses that are effective at preventing establishment of individual pathogens. Reviewed are studies relevant to the use of parasite hsps as vaccine components, with emphasis on those from schistosomes, malaria, chlamydial, and mycobacterial parasites.