Salivary testosterone diurnal variation and psychopathology in adolescent males and females: Individual differences and developmental effects
Salivary testosterone diurnal variation and psychopathology in adolescent males and females: Individual differences and developmental effects
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DOI：
10.1017/s0954579403000233
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发表时间：
2003-03-01
影响因子：
3.3
通讯作者：
Hastings, P
中科院分区：
文献类型：
--
作者：
Granger, DA;Shirtcliff, EA;Hastings, P
对213名青少年(男孩106名，女孩107名；平均年龄13.66岁)唾液睾酮的个体差异与外化和内化精神病理学的关系进行了研究。获得了行为问题和精神症状的自我报告和父母报告。潜伏性焦虑-抑郁、破坏性行为和注意力问题的结构是使用多特征、多方法程序开发的。在多天的上午、中午和下午晚些时候采集唾液样本，然后进行睾丸激素检测。在六个采样场合中，得出了睾酮水平和日变化的潜在结构。结构方程按性别分别对问题行为和睾丸激素的个体内和个体间差异之间的关系进行了建模。对于男孩来说，较低的睾酮水平和一天中下降较慢的睾酮水平与较高水平的焦虑-抑郁和注意力问题有关。这些联系并没有受到青春期发育的影响。对于女孩来说，睾酮水平的急剧下降与较高水平的破坏性行为问题有关，但这种联系只有在将青春期发展作为调节因素后才明显。模特。这些发现提出了一些新的问题，即睾丸激素和青少年问题行为之间的联系的性质和程度。
Individual differences in salivary testosterone were examined in 213 adolescents (106 boys, 107 girls; mean age 13.66 years) in relation to externalizing and internalizing psychopathology. Self- and parent-report measures of behavior problems and psychiatric symptoms were obtained. Latent anxiety-depression, disruptive behavior, and attention problem constructs were developed using multitrait, multimethod procedures. Saliva samples were collected in the morning, midday, and late afternoon on multiple days and were later assayed for testosterone. Latent constructs were derived for testosterone level and diurnal variation across the six sampling occasions. Structural equations modeled relationships between problem behavior and intra- and interindividual differences in testosterone separately by gender. For boys, lower levels of testosterone and testosterone levels that decreased more slowly across the day were related to higher levels of anxiety-depression and attention problems. These associations were not moderated by pubertal development. For girls,steep declines in testosterone production across the day related to higher levels of disruptive behavior problems, but this association was only evident after including pubertal development as a moderator in the. model. These findings raise novel questions regarding the nature and magnitude of links between testosterone and problem behavior in youth.