Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep.
Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep.
复制标题
多巴胺 D3 激动剂进入黑质会加重猝倒，但不会改变睡眠。
DOI：
10.1097/00001756-199911260-00046
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发表时间：
1999
期刊：
影响因子：
1.7
通讯作者：
Nishino,S
中科院分区：
文献类型：
--
作者：
Honda,K;Riehl,J;Mignot,E;Nishino,S
我们最近证明，多巴胺能d2 / d3激动剂局部灌注到腹侧被盖区（VTA）显著加重发作性睡症杜宾犬的猝倒和增加睡眠。我们进一步评估了中间纹状体多巴胺能系统的作用，发现局部向黑质（SN）灌注喹匹罗和7-OH-DPAT显著加重了猝倒，而灌注d2 / d3拮抗剂显著减轻了猝倒。d1激动剂和d1拮抗剂都不能改变中风。喹匹罗SN灌注对睡眠无明显改善作用，而VTA灌注明显增加困倦状态。虽然VTA和SN多巴胺能神经元的自调节参与了猝倒的调节，但这两种结构在调节睡眠方面具有不同的作用。
We have recently demonstrated that local perfusion of dopaminergic D 2/D 3 agonists into the ventral tegmental area (VTA) significantly aggravates cataplexy and increases sleep in narcoleptic Dobermans. We further assessed the roles of the mesostriatal dopaminergic system and found that local perfusion of quinpirole and 7-OH-DPAT into the substantia nigra (SN) significantly aggravated cataplexy, while perfusion of a D 2/D 3 antagonist significantly reduced cataplexy. Neither a D 1 agonist nor a D 1 antagonist modified cataplexy. SN perfusion of quinpirole did not significantly modify sleep, while VTA perfusion significantly increased the drowsy state. Although autoregulation of the VTA and SN dopaminergic neurons are involved in the regulation of cataplexy, both structures have distinct roles for the regulation of sleep.