Neuromagnetic biomarkers of visuocortical development in healthy children
Neuromagnetic biomarkers of visuocortical development in healthy children
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DOI：
10.1016/j.clinph.2010.03.029
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发表时间：
2010-09-01
影响因子：
4.7
通讯作者：
Liu, Yang
中科院分区：
文献类型：
--
作者：
Chen, Yangmei;Xiang, Jing;Liu, Yang
目的：本研究的目的是探讨非侵入性的生物标志物的健康children.Methods：60名健康儿童和20名成人进行了研究与全头脑磁图（MEG）系统。成年人被包括在内，以找出何时标志物稳定。结果：儿童视觉诱发磁场（VEFs）在77 +/- 8 ms（M75）、111 +/- 9 ms（M100）和150 +/- 11 ms（M145）处有3个反应峰。M75和M100潜伏期随年龄增长而缩短（P < 0.01）。M100/M75波幅比随年龄增长而显著增加（P < 0.001）。M75和M145左右枕叶脑源像差异随年龄增长而显著增大结论：M75和M100的潜伏期以及M100/M75的波幅比是儿童视功能发育的可靠生物标志物。儿童期视觉功能的发展是非侵入性测量的。本研究结果为定量鉴定脑功能障碍儿童的发育迟缓和/或视功能异常奠定了基础。(C)2010年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: The objective of the present study was to investigate noninvasive biomarkers for visuocortical development in healthy children.Methods: Sixty healthy children and 20 adults were studied with a whole-head magnetoencephalography (MEG) system. The adults were included to find out when the markers stabilize. Visual evoked magnetic fields (VEFs) were evoked with full-field pattern-reversal checks.Results: Three response peaks were identified at 77 +/- 8 ms (M75), 111 +/- 9 ms (M100) and 150 +/- 11 ms (M145) for children. The latency of M75 and M100 decreased with age (p < 0.01). The amplitude ratio of M100/M75 increased significantly with age (p < 0.001). The differences of MEG source images between the left and right occipital cortices for M75 and M145 increased significantly with age (r = 0.47 and 0.46, respectively, p < 0.01).Conclusions: The latency of M75 and M100 and the amplitude ratio of M100/M75 are robust biomarkers for the development of visual function in children.Significance: The development of visual function in childhood is noninvasively measurable. The results lay a foundation for quantitative identification of developmental delay and/or abnormalities of visual function in children with brain disorders. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.