Optimising screening for cognitive dysfunction in bipolar disorder: Validation and evaluation of objective and subjective tools
Optimising screening for cognitive dysfunction in bipolar disorder: Validation and evaluation of objective and subjective tools
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DOI：
10.1016/j.jad.2015.07.039
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发表时间：
2015-11-15
影响因子：
6.6
通讯作者：
Miskowiak, Kamilla W.
中科院分区：
文献类型：
--
作者：
Jensen, Johan Hoy;Stottrup, Mette Marie;Miskowiak, Kamilla W.
引言：认知障碍在双相情感障碍中很常见，并导致社会职业困难。目的是验证和评估用于筛查和监测认知障碍的工具，并提高对认知测量与社会职业能力之间关联的理解。方法：部分或完全缓解的双相情感障碍患者（n=84）和健康对照组（n=68）采用精神病学认知障碍筛查（SEW）进行评估，双相情感障碍认知主诉评定量表（COBRA），并建立神经心理学测验和主观评定量表。采用功能评定简易测验、汉密尔顿抑郁量表17项和杨氏躁狂量表评定患者的社会职业功能和情感症状。SCIP和COBRA的并发效度进行了评估，建立客观和主观的认知措施的相关性，并决定与接收器操作特征分析的有效性。进行相关性和线性回归分析，以确定客观和主观认知障碍，社会职业difficulties.Results之间的关联：SAP和COBRA相关性强，建立客观和主观的认知措施，分别。SCIP检测认知功能障碍的灵敏度和特异性高于COBRA或联合SUP-COBRA测量。客观和主观认知障碍之间的相关性弱，但都与社会职业difficulties.Limitations：影响的老龄化没有investigated.Conclusions：SOP和COBRA是有效的客观和主观的认知障碍双相情感障碍的检测。认知功能障碍的筛查应采用SOP等客观措施进行。(C)2015 Elsevier B. V.版权所有。
Introduction: Cognitive impairment is common in bipolar disorder and contributes to socio-occupational difficulties. The objective was to validate and evaluate instruments to screen for and monitor cognitive impairments, and improve the understanding of the association between cognitive measures and socio-occupational capacity.Methods: Patients with bipolar disorder in partial or full remission (n=84) and healthy controls (n=68) were assessed with the Screen for Cognitive Impairment in Psychiatry (SEW), Cognitive Complaints in Bipolar Disorder Rating Scale (COBRA), and established neuropsychological tests and subjective rating scales. Socio-occupational function and affective symptoms were evaluated with the Functional Assessment Short Test, and the Hamilton Depression Rating Scale 17-items and Young Mania Rating Scale, respectively. Concurrent validity of the SCIP and COBRA were assessed by correlation with established objective and subjective cognitive measures, and decision validity was determined with Receiver-Operating-Characteristic analyses. Correlations and linear regression analyses were conducted to determine the associations between objective and subjective cognitive impairment, and socio-occupational difficulties.Results: The sap and COBRA correlated strongly with established objective and subjective cognitive measures, respectively. The SCIP yielded higher sensitivity and specificity for detection of cognitive dysfunction than the COBRA or a combined SUP-COBRA measure. Correlations between objective and subjective cognitive impairment were weak but both were associated with socio-occupational difficulties.Limitations: Influence of ageing was not investigated.Conclusions: The SOP and COBRA are valid for detection of objective and subjective cognitive impairment in bipolar disorder. Screening for cognitive dysfunction should be conducted with an objective measure like the SOP. (C) 2015 Elsevier B.V. All rights reserved.