THE LIMITED ROLE OF CORTICOSTEROIDS IN AMELIORATING EXPERIMENTAL DOXORUBICIN SKIN TOXICITY IN THE MOUSE
THE LIMITED ROLE OF CORTICOSTEROIDS IN AMELIORATING EXPERIMENTAL DOXORUBICIN SKIN TOXICITY IN THE MOUSE
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DOI：
10.1007/bf00578557
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发表时间：
1980-01-01
影响因子：
3
通讯作者：
CHEN, HSG
中科院分区：
文献类型：
--
作者：
DORR, RT;ALBERTS, DS;CHEN, HSG
局部皮肤坏死是阿霉素(阿霉素)渗入人体的严重并发症。皮内注射阿霉素(ID)在小鼠身上造成皮肤损伤，然后对一些局部皮质类固醇干预进行研究。最有效的局部解毒剂是小剂量(2.5 mg)氢化可的松(HC)，但仅对小剂量阿霉素(0.05 mg)。其他疗效较差的辅料包括地塞米松-碳酸氢钠和中等剂量的HC(6.25毫克)。较大剂量的IDHC并不能防止阿霉素的局部毒性，而是对皮肤本身有毒性。全身皮质类固醇也同样无效。低IDHC剂量的优越性，添加剂(碳酸氢钠，局部使用的HC乳膏)的无效，以及大剂量阿霉素ID挑战(0.5 mg)的耐药性，表明皮质类固醇在实验性阿霉素皮肤毒性管理中的作用有限。
Local skin necrosis is a serious complication of doxorubicin (Adriamycin) infiltration in man. Intradermal (ID) doxorubicin injection was used in the mouse to create skin lesions, after wich a number of local corticosteroid interventions were studied. The most effective local antidote was low-dose (2.5 mg) hydrocortisone (HC), but only against the low-dose doxorubicin challege (0.05 mg). Other andidotes with lesser effectiveness included dexamethasone-sodium bicarbonate and an intermediate dose of HC (6.25 mg). Larger doses of ID HC did not prevent local doxorubicin toxicity and were inherently toxic to the skin. Systemic corticosteroids were similarly ineffective. The superiority of the low ID HC dose, the ineffectiveness of additions (sodium bicarbonate, topical HC cream), and the resistance of the high-dose doxorubicin ID challenge (0.5 mg) suggests a limited role for corticosteroids in the management of experimental doxorubicin skin toxicity.