Early colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Early colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
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DOI：
10.1093/annonc/mdt354
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发表时间：
2013-10-01
影响因子：
50.5
通讯作者：
Arnold, D.
中科院分区：
文献类型：
--
作者：
Labianca, R.;Nordlinger, B.;Arnold, D.
结直肠癌（CRC）是男性第三大常见肿瘤，女性第二大常见肿瘤，占全球所有肿瘤类型的10%。男性的发病率较高（比率：1.4），几个地区之间的男女发病率相差10倍。估计每年有608000人死亡（占所有癌症死亡的0.8%），CRC是世界上第四大常见的癌症相关死亡原因[1]。作为一般观察结果，在大肠癌总体风险较低的国家，其发病率一直在增加，而在历史上的高风险国家，（西欧和澳大利亚）或降低（美国、加拿大和新西兰）[2]。西北欧和东南欧之间的发病率和死亡率存在梯度：在西班牙和东欧等历史上低风险地区，新的CRC病例增加[3]。这种不断增长的发病率反映了生活方式行为的改变及其与“西化”相关的后果，如肥胖，缺乏运动，大量饮酒，大量红肉消费和吸烟。
Colorectal cancer (CRC) is the third most common tumour in men and the second in women, accounting for 10% of all tumour types worldwide. Incidence is higher in males (ratio: 1.4) and for both genders there is a 10-fold difference in incidence between several regions. With 608 000 deaths estimated each year (∼ 8% of all cancer deaths), CRC is the fourth most common cancer-related cause of death in the world [1].As a general observation, there has been an increasing incidence in countries where the overall risk of large bowel cancer was low, while in historically high-risk countries either a stabilisation (Western Europe and Australia) or a decrease (USA, Canada and New Zealand) in incidence was reported [2]. A gradient of incidence and mortality between North Western and South Eastern Europe has been observed: new CRC cases increased in historically low-risk areas such as Spain and Eastern Europe [3]. This growing incidence reflects modifications in lifestyle behaviours and their consequences related with ‘westernisation’such as obesity, physical inactivity, heavy alcohol consumption, high red meat consumption and smoking.