Bacterial Protein Synthesis as a Target for Antibiotic Inhibition
Bacterial Protein Synthesis as a Target for Antibiotic Inhibition
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DOI：
10.1101/cshperspect.a025361
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发表时间：
2016-09-01
影响因子：
5.4
通讯作者：
Wilson, Daniel N.
中科院分区：
文献类型：
--
作者：
Arenz, Stefan;Wilson, Daniel N.
蛋白质合成发生在大分子机器上，称为核糖体。细菌核糖体和翻译机器代表了细胞中抗生素的主要靶标之一。因此，对核糖体靶向抗生素的结构和生物化学研究不仅提供了对抗生素的作用机制和耐药性的深入了解，而且还提供了对蛋白质合成基本过程的深入了解。这篇综述总结了我们对蛋白质合成的理解的最新进展，特别是关于核糖体复合物的X射线和冷冻电子显微镜（cryo-EM）结构，并强调了不同的翻译步骤，这些步骤是由不同的已知抗生素阵列所靶向的。这些发现对于正在进行的开发新型和改进的抗菌剂以对抗快速出现的多药耐药致病菌将是重要的。
Protein synthesis occurs on macromolecular machines, called ribosomes. Bacterial ribosomes and the translational machinery represent one of the major targets for antibiotics in the cell. Therefore, structural and biochemical investigations into ribosome-targeting antibiotics provide not only insight into the mechanism of action and resistance of antibiotics, but also insight into the fundamental process of protein synthesis. This review summarizes the recent advances in our understanding of protein synthesis, particularly with respect to X-ray and cryoelectron microscopy (cryo-EM) structures of ribosome complexes, and highlights the different steps of translation that are targeted by the diverse array of known antibiotics. Such findings will be important for the ongoing development of novel and improved antimicrobial agents to combat the rapid emergence of multidrug resistant pathogenic bacteria.