Stroke therapy in traditional Chinese medicine (TCM): prospects for drug discovery and development
Stroke therapy in traditional Chinese medicine (TCM): prospects for drug discovery and development
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DOI：
10.1016/s0165-6147(98)01276-0
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发表时间：
1999-05-01
影响因子：
13.8
通讯作者：
Sucher, NJ
中科院分区：
文献类型：
--
作者：
Gong, XD;Sucher, NJ
中风引起的脑损伤是世界范围内发达国家和发展中国家的一个主要且日益严重的公共卫生问题。中国在使用传统中药治疗中风方面的丰富经验表明，中药制剂是有效的，副作用很少或没有副作用。中国有100多种传统药物用于中风治疗。近年来的临床研究证实了其对中风的治疗作用。大量的化合物已经从中药中分离出来，这些资源中的大多数尚未被表征用于药理学目的。在这里，本文解释了中医如何为实施旨在开发新药的战略重点药理学研究计划提供广泛和丰富的知识基础。
Brain injuries resulting from stroke are a major and increasing public health problem in both developed and developing countries worldwide. China's extensive experience in the use of traditional Chinese medicines (TCMs) in stroke thera py indicates that TCM preparations are effective, with few or no side-effects. There are more than 100 traditional medicines in use for stroke thera py in China. Some of their therapeutic effects in stroke have been confirmed by recent clinical studies. A large number of compounds have been isolated from TCMs and most of these resources have not yet been characterized for pharmacological purposes. Here, this article explains how TCM provides an extensive and knowledge-rich foundation for implementing a strategically focused pharmacological research programme aimed at the development of new drugs.