The perinucleolar compartment: RNA metabolism and cancer.
The perinucleolar compartment: RNA metabolism and cancer.
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DOI：
10.1007/978-3-642-31659-3_6
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发表时间：
2013
影响因子：
--
通讯作者：
Huang, Sui
中科院分区：
文献类型：
--
作者：
Norton, John T;Huang, Sui
核仁周室（PNC）是一个与核仁相关但结构上不同的核亚结构。PNC含有几种RNA加工蛋白和几种RNA pol III转录物，它们形成新的复合物。如通过细胞培养实验和人肿瘤样品所确定的，PNC仅在癌细胞中形成，并且具有一个或多个PNC的群体中癌细胞的百分比与该细胞群体的恶性程度直接相关。因此，PNC被开发为几种恶性肿瘤的预后标志物。已证明癌细胞中的PNC消除可用作筛选方法以发现用于阐明PNC生物学的探针化合物和发现具有开发为最低毒性抗癌药物的潜力的化合物。
The perinucleolar compartment (PNC) is a nuclear substructure associated with, but structurally distinct from, the nucleolus. The PNC contains several RNA processing proteins and several RNA pol III transcripts, which form novel complexes. As determined by cell culture experiments and human tumor samples, the PNC forms exclusively in cancer cells and the percentage of cancer cells in a population that have one or more PNCs directly correlates with the malignancy of that population of cells. Therefore, the PNC is being developed as a prognostic marker for several malignancies. PNC elimination in cancer cells has proven to be a useful as screening method to discover probe compounds used to elucidate PNC biology and to discover compounds with the potential to be developed as minimally toxic anti-cancer drugs.