Methylxanthine Drug Monitoring with Wearable Sweat Sensors
Methylxanthine Drug Monitoring with Wearable Sweat Sensors
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DOI：
10.1002/adma.201707442
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发表时间：
2018-06-06
影响因子：
29.4
通讯作者：
Javey, Ali
中科院分区：
文献类型：
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作者：
Tai, Li-Chia;Gao, Wei;Javey, Ali
药物监测在兴奋剂控制和精准医疗中发挥着至关重要的作用。它帮助医生定制药物剂量以获得最佳益处，跟踪患者对处方的依从性，并了解药物的复杂药代动力学。传统的药物测试依赖于侵入性抽血。虽然尿液和汗液是有吸引力的替代生物流体，但最先进的方法需要单独的样本收集和处理步骤，并且无法提供实时信息。在这里，提出了一种配备电化学差分脉冲伏安法传感模块的可穿戴平台，用于药物监测。选择甲基黄嘌呤药物咖啡因来展示平台的功能。汗液中的咖啡因水平在各种条件下进行监测，例如药物剂量和药物摄入后的测量时间。观察到增加剂量后汗液咖啡因水平升高和可确认的咖啡因生理趋势。这项工作利用可穿戴汗液传感平台实现无创和连续的护理点药物监测和管理。
Drug monitoring plays crucial roles in doping control and precision medicine. It helps physicians tailor drug dosage for optimal benefits, track patients' compliance to prescriptions, and understand the complex pharmacokinetics of drugs. Conventional drug tests rely on invasive blood draws. While urine and sweat are attractive alternative biofluids, the state-of-the-art methods require separate sample collection and processing steps and fail to provide real-time information. Here, a wearable platform equipped with an electrochemical differential pulse voltammetry sensing module for drug monitoring is presented. A methylxanthine drug, caffeine, is selected to demonstrate the platform's functionalities. Sweat caffeine levels are monitored under various conditions, such as drug doses and measurement time after drug intake. Elevated sweat caffeine levels upon increasing dosage and confirmable caffeine physiological trends are observed. This work leverages a wearable sweat sensing platform toward noninvasive and continuous point-of-care drug monitoring and management.