Stimuli-free auto-modulated material release from mesoporous nanocompartment films.
Stimuli-free auto-modulated material release from mesoporous nanocompartment films.
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DOI：
10.1021/ja076139s
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发表时间：
2008-02
影响因子：
15
通讯作者：
Qingmin Ji;Masahiko Miyahara;Jonathan P. Hill;S. Acharya;A. Vinu;S. Yoon;Jong‐Sung Yu;K. Sakamoto;K. Ariga
中科院分区：
文献类型：
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作者：
Qingmin Ji;Masahiko Miyahara;Jonathan P. Hill;S. Acharya;A. Vinu;S. Yoon;Jong‐Sung Yu;K. Sakamoto;K. Ariga
采用层层法（LbL）制备了由二氧化硅颗粒和空心二氧化硅胶囊组成的介孔纳米隔室膜。所得介孔纳米隔室膜具有特殊的分子封装和释放能力，使得通过嵌入膜中的稳健二氧化硅胶囊容器的中孔通道实现水或药物分子的无刺激自动调节逐步释放。可重复地观察到水的逐步释放，其源于水从中孔通道蒸发到外部与水从容器内部毛细渗透到中孔通道之间的非平衡速率。它被推广到其他物质的蒸发，香料，柠檬烯。还测试了防晒紫外线吸收剂（UV-S1）的控释应用，以避免其在水中的快速溶解并延长其对有害紫外线辐射的预防作用。UV-S1被成功地截留在介孔纳米隔室膜内，并以延长的逐步模式释放。本研究中开发的纳米隔室膜是有前途的药物递送材料，因为它们允许逐渐释放治疗剂，并可能改善其疗效。
Mesoporous nanocompartment films composed of silica particles and hollow silica capsules were prepared by the layer-by-layer (LbL) technique. The resulting mesoporous nanocompartment films possess special molecular encapsulation and release capabilities so that stimuli-free auto-modulated stepwise release of water or drug molecules was achieved through the mesopore channels of robust silica capsule containers embedded in the film. Stepwise release of water was reproducibly observed that originates in the non-equilibrated rates between evaporation of water from the mesopore channels to the exterior and the capillary penetration of water from container interior to the mesopore channels. It was generalized to evaporation of other substances, fragrances, limonene. Application was also tested in the controlled release of the sunscreen UV-absorber (UV-S1) for circumvention of its rapid dissolution in water and prolongation of its prophylactic effect toward harmful ultraviolet radiation. UV-S1 was successfully entrapped within the mesoporous nanocompartment films and was released in a prolonged stepwise mode. The nanocompartment films developed in this research are promising materials for drug delivery since they allow gradual release of therapeutic agents with likely related improvements in their efficacy.