Aqueous Flow Hydroxycarbonylation of Aryl Halides Catalyzed by an Amphiphilic Polymer-Supported Palladium Diphenylphosphine Catalyst
Aqueous Flow Hydroxycarbonylation of Aryl Halides Catalyzed by an Amphiphilic Polymer-Supported Palladium Diphenylphosphine Catalyst
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两亲性聚合物负载二苯基膦钯催化剂催化芳基卤化物的水流羟基羰基化反应
DOI：
10.1055/s-0037-1611769
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发表时间：
2019
期刊：
影响因子：
2
通讯作者：
Yasuhiro Uozumi
中科院分区：
文献类型：
--
作者：
Takao Osako;Reinhard Kaiser;Kaoru Torii;Yasuhiro Uozumi
建立了钯催化芳基卤化物羟基羰基化的水连续流反应体系。在固定在两亲性聚苯乙烯-聚乙二醇树脂上的钯-二苯基膦络合物的流动反应器中，芳基卤化物在水溶液中的流动羟基羰基化反应有效地进行，得到相应的苯甲酸，收率很高。
An aqueous continuous-flow reaction system is developed for the palladium-catalyzed hydroxycarbonylation of aryl halides. Flow hydroxycarbonylation of aryl halides in aqueous solution proceeds efficiently in a flow reactor containing a palladium–diphenylphosphine complex immobilized on an amphiphilic polystyrene–poly(ethylene glycol) resin to give the corresponding benzoic acids in excellent yields.