Distinct genetic alterations in colorectal cancer.
Distinct genetic alterations in colorectal cancer.
复制标题
结直肠癌的明显遗传改变。
DOI：
10.1371/journal.pone.0008879
复制
发表时间：
2010-01-26
期刊：
影响因子：
3.7
通讯作者：
Brim H
中科院分区：
文献类型：
--
作者：
Ashktorab H;Schäffer AA;Daremipouran M;Smoot DT;Lee E;Brim H
Colon cancer (CRC) development often includes chromosomal instability (CIN) leading to amplifications and deletions of large DNA segments. Epidemiological, clinical, and cytogenetic studies showed that there are considerable differences between CRC tumors from African Americans (AAs) and Caucasian patients. In this study, we determined genomic copy number aberrations in sporadic CRC tumors from AAs, in order to investigate possible explanations for the observed disparities. We applied genome-wide array comparative genome hybridization (aCGH) using a 105k chip to identify copy number aberrations in samples from 15 AAs. In addition, we did a population comparative analysis with aCGH data in Caucasians as well as with a widely publicized list of colon cancer genes (CAN genes). There was an average of 20 aberrations per patient with more amplifications than deletions. Analysis of DNA copy number of frequently altered chromosomes revealed that deletions occurred primarily in chromosomes 4, 8 and 18. Chromosomal duplications occurred in more than 50% of cases on chromosomes 7, 8, 13, 20 and X. The CIN profile showed some differences when compared to Caucasian alterations. Chromosome X amplification in male patients and chromosomes 4, 8 and 18 deletions were prominent aberrations in AAs. Some CAN genes were altered at high frequencies in AAs with EXOC4, EPHB6, GNAS, MLL3 and TBX22 as the most frequently deleted genes and HAPLN1, ADAM29, SMAD2 and SMAD4 as the most frequently amplified genes. The observed CIN may play a distinctive role in CRC in AAs.
登录
查看更多内容
DOI：
10.1083/jcb.200709076
发表时间：
2008-06-16
期刊：
The Journal of cell biology
影响因子：
--
作者：
Sakurai-Yageta M;Recchi C;Le Dez G;Sibarita JB;Daviet L;Camonis J;D'Souza-Schorey C;Chavrier P
通讯作者：
Chavrier P
影响因子：
4.4
作者：
Martínez-Gimeno, M;Gamundi, MJ;Carballo, M
通讯作者：
Carballo, M
DOI：
10.1073/pnas.0704652104
发表时间：
2007-11-20
影响因子：
11.1
作者：
Shen, Lanlan;Toyota, Minoru;Issa, Jean-Pierre J.
通讯作者：
Issa, Jean-Pierre J.
影响因子：
10.6
作者：
Edwards DR;Handsley MM;Pennington CJ
通讯作者：
Pennington CJ
影响因子：
8
作者：
Georgiades, IB;Curtis, LJ;Wyllie, AH
通讯作者：
Wyllie, AH