Connection between histone H2A variants and chromatin remodeling complexes
Connection between histone H2A variants and chromatin remodeling complexes
复制标题
DOI：
10.1139/o08-140
复制
发表时间：
2009-02-01
影响因子：
2.9
通讯作者：
Cote, Jacques
中科院分区：
文献类型：
--
作者：
Altaf, Mohammed;Auger, Andreanne;Cote, Jacques
真核基因组组织成染色质，使其无法接触基因转录和 DNA 复制、重组和修复所需的因子。除了组蛋白修饰酶和 ATP 依赖性染色质重塑复合物（通过改变染色质结构在调节许多核过程中发挥关键作用）之外，细胞还开发了一种通过整合组蛋白变体来调节染色质结构的机制。这些变体在整个细胞周期中被整合到基因组的特定区域。 H2A.Z 是所有进化上保守的 H2A 变体，执行几个看似不相关甚至相反的功能。另一种 H2A 变体 H2A.X 在细胞对 DNA 损伤的反应中发挥着非常重要的作用。这篇综述总结了我们对 H2A.Z 和 H2A.X 在染色质结构和功能调节中的作用的理解的最新进展，重点关注它们与染色质修饰和重塑复合物的功能联系。
The organization of the eukaryotic genome into chromatin makes it inaccessible to the factors required for gene transcription and DNA replication, recombination, and repair. In addition to histone-modifying enzymes and ATP-dependent chromatin remodeling complexes, which play key roles in regulating many nuclear processes by altering the chromatin structure, cells have developed a mechanism of modulating chromatin structure by incorporating histone variants. These variants are incorporated into specific regions of the genome throughout the cell cycle. H2A.Z, which is ail evolutionarily conserved H2A variant, performs several seemingly unrelated and even contrary functions. Another H2A variant, H2A.X, plays a very important role in the cellular response to DNA damage. This review Summarizes the recent developments in our understanding of the role of H2A.Z and H2A.X in the regulation of chromatin structure and function, focusing on their functional links with chromatin modifying and remodeling complexes.