Connexin 43 and Mitochondria in Cardiovascular Health and Disease
Connexin 43 and Mitochondria in Cardiovascular Health and Disease
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DOI：
10.1007/978-3-319-55330-6_12
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发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Schulz, Rainer
中科院分区：
文献类型：
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作者：
Boengler, Kerstin;Schulz, Rainer
连接蛋白43（Cx43）是心室肌细胞中主要的连接蛋白。六个Cx43蛋白在肌膜处组装成所谓的半通道，并且相对的半通道形成间隙连接，其允许小分子和电流在相邻细胞之间流动。除了定位于质膜外，Cx43还存在于心肌细胞线粒体中，在氧消耗和钾通量方面，Cx43对线粒体功能很重要。缝隙连接和线粒体Cx43的表达在多种病理生理条件下发生改变，其中包括高血压、肥大、高胆固醇血症、缺血/再灌注损伤、梗死后重塑和心力衰竭。本文就Cx43在心血管疾病中的作用及线粒体Cx43在心脏保护中的重要作用作一综述。
Connexin 43 (Cx43) is the major connexin protein in ventricular cardiomyocytes. Six Cx43 proteins assemble into so-called hemichannels at the sarcolemma and opposing hemichannels form gap junctions, which allow the passage of small molecules and electrical current flow between adjacent cells. Apart from its localization at the plasma membrane, Cx43 is also present in cardiomyocyte mitochondria, where it is important for mitochondrial function in terms of oxygen consumption and potassium fluxes. The expression of gap junctional and mitochondrial Cx43 is altered under several pathophysiological conditions among them are hypertension, hypertrophy, hypercholesterolemia, ischemia/reperfusion injury, post-infarction remodeling, and heart failure. The present review will focus on the role of Cx43 in cardiovascular diseases and will highlight the importance of mitochondrial Cx43 in cardioprotection.