Running enhances neurogenesis, learning, and long-term potentiation in mice
Running enhances neurogenesis, learning, and long-term potentiation in mice
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DOI：
10.1073/pnas.96.23.13427
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发表时间：
1999-11-09
影响因子：
11.1
通讯作者：
Gage, FH
中科院分区：
文献类型：
--
作者：
van Praag, H;Christie, BR;Gage, FH
跑步会增加海马体齿状回的神经生成，海马体是一种对记忆功能很重要的大脑结构。因此，空间学习和长期增强（LTP）在小鼠组中进行了测试，这些小鼠分别被置于跑步轮（跑步者）和标准条件下（对照组），小鼠被注射溴脱氧尿苷来标记分裂细胞，并在莫里斯水迷宫中训练。研究了小鼠海马齿状回和CA1区LTP的变化。跑步可以改善水迷宫的表现，增加溴脱氧尿嘧啶阳性细胞数量，并选择性地增强齿状回LTP。我们的研究结果表明，体育活动可以调节海马神经发生、突触可塑性和学习。
Running increases neurogenesis in the dentate gyrus of the hippocampus, a brain structure that is important for memory function. Consequently, spatial learning and long-term potentiation (LTP) were tested in groups of mice housed either with a running wheel (runners) or under standard conditions (controls), Mice were injected with bromodeoxyuridine to label dividing cells and trained in the Morris water maze. LTP was studied in the dentate gyrus and area CA1 in hippocampal slices from these mice. Running improved water maze performance, increased bromodeoxyuridine-positive cell numbers, and selectively enhanced dentate gyrus LTP, Our results indicate that physical activity can regulate hippocampal neurogenesis, synaptic plasticity, and learning.