The therapeutic potential of targeting chemokine signalling in the treatment of chronic pain.
The therapeutic potential of targeting chemokine signalling in the treatment of chronic pain.
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DOI：
10.1111/jnc.13927
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发表时间：
2017-05
影响因子：
4.7
通讯作者：
Malcangio M
中科院分区：
文献类型：
--
作者：
Montague K;Malcangio M
慢性疼痛是一种令人痛苦的状况，即使疼痛刺激（无论是手术还是疾病相关）已经消退，也会经历这种状况。目前对慢性疼痛的治疗显示出有限的疗效，并伴有许多不良副作用，因此需要开发新的更有效的疗法。慢性疼痛的潜在机制目前尚未完全了解，尽管临床前模型在过去十年中大大促进了这一理解的进展。慢性疼痛的潜在机制最初被认为是神经中心的。然而，我们现在认识到，非神经元细胞通过与神经元的通讯在伤害性信号传导中发挥着重要作用。介导神经元/非神经元通信的主要信号传导途径之一是趋化因子信号传导。在这篇综述中，我们讨论了选定的趋化因子，据报道，在各种临床前模型的慢性疼痛的机制中发挥了关键作用。针对本综述中讨论的每种趋化因子的方法都有其优点和缺点;然而，抑制趋化因子作用正在成为一种创新的治疗策略，现在已经进入临床，其中趋化因子Fractalkine及其CX 3 CR 1受体处于领先地位。 这篇文章是特别文章系列“痛苦”的一部分。
Chronic pain is a distressing condition, which is experienced even when the painful stimulus, whether surgery or disease related, has subsided. Current treatments for chronic pain show limited efficacy and come with a host of undesirable side‐effects, and thus there is a need for new, more effective therapies to be developed. The mechanisms underlying chronic pain are not fully understood at present, although pre‐clinical models have facilitated the progress of this understanding considerably in the last decade. The mechanisms underlying chronic pain were initially thought to be neurocentric. However, we now appreciate that non‐neuronal cells play a significant role in nociceptive signalling through their communication with neurons. One of the major signalling pathways, which mediates neuron/non‐neuronal communication, is chemokine signalling. In this review, we discuss selected chemokines that have been reported to play a pivotal role in the mechanisms underlying chronic pain in a variety of pre‐clinical models. Approaches that target each of the chemokines discussed in this review come with their advantages and disadvantages; however, the inhibition of chemokine actions is emerging as an innovative therapeutic strategy, which is now reaching the clinic, with the chemokine Fractalkine and its CX 3 CR 1 receptor leading the way. This article is part of the special article series “Pain”.