CARE4Kids Study: Endophenotypes of Persistent Post-Concussive Symptoms in Adolescents: Study Rationale and Protocol.
CARE4Kids Study: Endophenotypes of Persistent Post-Concussive Symptoms in Adolescents: Study Rationale and Protocol.
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CARE4Kids 研究：青少年持续性脑震荡后症状的内表型：研究原理和方案。
DOI：
10.1089/neu.2023.0073
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发表时间：
2024
影响因子：
4.2
通讯作者：
Rosenbaum,PhilipE
中科院分区：
文献类型：
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作者：
Giza,ChristopherC;Gioia,Gerard;Cook,LawrenceJ;Asarnow,Robert;Snyder,Aliyah;Babikian,Talin;Thompson,Paul;Bazarian,JefferyJ;Whitlow,ChristopherT;Miles,ChristopherM;Otallah,Scott;Kamins,Joshua;Didehbani,Nyaz;Rosenbaum,PhilipE
在急性期对青年脑震荡的治疗不断发展，这导致了直接护理指南的出现。虽然脑震荡后的症状通常在14-28天内消退，但一部分（约20%）青少年认可持续性脑震荡后症状（PPCS）超出正常消退。本报告概述了一项响应国家神经疾病和中风研究所呼吁的发展和初步临床验证客观的生物学措施，以预测青少年PPCS的风险。我们描述了我们招募11至17岁脑震荡青少年的发展队列，并收集自主神经，神经认知，生物流体和成像生物标志物的计划。这些措施中最有前途的将在一个单独的脑震荡青年验证队列中进行验证，并将开发和传播最终的临床有用算法。在完成这项研究后，我们将产生一组预测PPCS高风险的措施，这将允许识别和测试干预措施，以防止PPCS在最高风险的青年。
Treatment of youth concussion during the acute phase continues to evolve, and this has led to the emergence of guidelines to direct care. While symptoms after concussion typically resolve in 14-28 days, a portion (∼20%) of adolescents endorse persistent post-concussive symptoms (PPCS) beyond normal resolution. This report outlines a study implemented in response to the National Institute of Neurological Diseases and Stroke call for the development and initial clinical validation of objective biological measures to predict risk of PPCS in adolescents. We describe our plans for recruitment of a Development cohort of 11- to 17-year-old youth with concussion, and collection of autonomic, neurocognitive, biofluid, and imaging biomarkers. The most promising of these measures will then be validated in a separate Validation cohort of youth with concussion, and a final, clinically useful algorithm will be developed and disseminated. Upon completion of this study, we will have generated a battery of measures predictive of high risk for PPCS, which will allow for identification and testing of interventions to prevent PPCS in the most high-risk youth.