Retinal circulatory changes related to retinopathy progression in insulin-dependent diabetes mellitus.
Retinal circulatory changes related to retinopathy progression in insulin-dependent diabetes mellitus.
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DOI：
10.1016/s0161-6420(85)33827-7
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发表时间：
1985-11
期刊：
影响因子：
13.7
通讯作者：
G. Feke;H. Tagawa;A. Yoshida;D. Goger;J. Weiter;S. Buzney;J. Mcmeel
中科院分区：
文献类型：
--
作者：
G. Feke;H. Tagawa;A. Yoshida;D. Goger;J. Weiter;S. Buzney;J. Mcmeel
为了量化糖尿病视网膜的血管恶化，我们测量了45例胰岛素依赖型糖尿病患者和17例正常对照者的视网膜循环变化，并根据视网膜病变的严重程度分为四组。采用无创激光多普勒技术测量沿颞视网膜动脉部位红细胞速度(V)的收缩/舒张变化。轻度视网膜病变组血流脉搏[V（收缩期）/V（舒张期）]比正常对照组低18% (P< 0.00001)，而重度视网膜病变组比轻度视网膜病变组高35% （P< 0.001）。在从轻度或中度到重度视网膜病变的进展过程中，三只眼睛的重复测量显示血流脉动和平均视网膜血流量都在进行性增加。血流搏动的改变似乎是糖尿病视网膜病变进展过程中血管改变的敏感指标。
To quantify the vascular deterioration of the diabetic retina, retinal circulatory changes in 45 insulin-dependent diabetic patients, and in 17 normal controls, were measured and divided into four groups according to severity of retinopathy. The noninvasive laser Doppler technique was used to measure the systolic/diastolic variation of red blood cell velocity (V) at sites along temporal retinal arteries. Flow pulsatility [V (systole)/V (diastole)] was 18% lower (P< 0.00001) in the mild-retinopathy group than in normal controls, but 35% higher (P< 0.001) in the severe-retinopathy group than in the mild-retinopathy group. Repeated measurements in three eyes during the progression from mild or moderate to severe retinopathy showed progressive increases in both flow pulsatility and mean retinal blood flow. Altered flow pulsatility appears to be a sensitive indicator of vascular alterations during the progression of diabetic retinopathy.